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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cdk5
cyclin-dependent kinase 5
MGI:101765
31 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdk5tm1Bibb/Cdk5tm1Bibb
Tg(Prnp-cre/ERT)28.4Ics/0
involves: C57BL/6 * SJL
abnormal contextual conditioning behavior J:124046
abnormal excitatory postsynaptic currents J:124046
abnormal excitatory postsynaptic potential J:124046
abnormal long term potentiation J:124046
abnormal spatial learning J:124046
abnormal synaptic plasticity J:124046
increased post-tetanic potentiation J:124046
Cdk5tm1Kul/Cdk5tm1Kul
involves: 129S4/SvJae * C57BL/6
abnormal cerebellar cortex morphology J:64289
abnormal cerebellar foliation J:64289
abnormal cerebral cortex morphology J:71181
abnormal cortical plate morphology J:71181
abnormal dentate gyrus morphology J:71181
abnormal facial nerve morphology J:64289
abnormal hippocampus layer morphology J:64289, J:71181
abnormal hypoglossal nerve morphology J:64289
abnormal locomotor behavior J:64289
abnormal motor neuron morphology J:64289, J:71181
abnormal olfactory bulb development J:71181
abnormal spinal cord ventral horn morphology J:64289
abnormal stratification in cerebral cortex J:64289
absent suckling reflex J:64289
chromatolysis J:71181
cyanosis J:64289
hypopnea J:64289
perinatal lethality, complete penetrance J:64289
unresponsive to tactile stimuli J:64289
weakness J:64289
Cdk5tm2Kul/Cdk5tm2Kul
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
no abnormal phenotype detected J:89561
Cdk5tm2Kul/Cdk5tm2Kul
Tg(Nefh-cre)12Kul/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
abnormal brain development J:89561
abnormal cerebellum development J:89561
abnormal hippocampus development J:89561
abnormal olfactory bulb development J:89561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory