Cdk5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk5
cyclin dependent kinase 5
MGI:101765

42 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk5^tm1Bibb/Cdk5^tm1Bibb Tg(Prnp-cre/ERT)28.4Ics/0 involves: C57BL/6 * SJL	abnormal contextual conditioning behavior	J:124046
	abnormal excitatory postsynaptic currents	J:124046
	abnormal excitatory postsynaptic potential	J:124046
	abnormal long-term potentiation	J:124046
	abnormal spatial learning	J:124046
	abnormal synaptic plasticity	J:124046
	increased post-tetanic potentiation	J:124046
Cdk5^tm1Kul/Cdk5^tm1Kul involves: 129S4/SvJae * C57BL/6	abnormal cerebellar cortex morphology	J:64289
	abnormal cerebellar foliation	J:64289
	abnormal cerebral cortex morphology	J:71181
	abnormal cortical plate morphology	J:71181
	abnormal dentate gyrus morphology	J:71181
	abnormal facial nerve morphology	J:64289
	abnormal hippocampus layer morphology	J:64289, J:71181
	abnormal hypoglossal nerve morphology	J:64289
	abnormal locomotor behavior	J:64289
	abnormal motor neuron morphology	J:64289, J:71181
	abnormal olfactory bulb development	J:71181
	abnormal spinal cord ventral horn morphology	J:64289
	abnormal stratification in cerebral cortex	J:64289
	absent suckling reflex	J:64289
	chromatolysis	J:71181
	cyanosis	J:64289
	hypopnea	J:64289
	perinatal lethality, complete penetrance	J:64289
	unresponsive to tactile stimuli	J:64289
	weakness	J:64289
Cdk5^tm2Kul/Cdk5^tm2Kul involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:89561
Cdk5^tm2Kul/Cdk5^tm2Kul Tg(Nefh-cre)12Kul/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal brain development	J:89561
	abnormal cerebellum development	J:89561
	abnormal hippocampus development	J:89561
	abnormal olfactory bulb development	J:89561
Tg(RNU6-1-RNAi:Cdk5)#Chad/0 C57BL/6J-Tg(RNU6-1-RNAi:Cdk5)#Chad	abnormal hair follicle dermal papilla morphology	J:255707
	abnormal hair follicle melanin granule distribution	J:255707
	abnormal melanogenesis	J:255707
	abnormal melanosome transport	J:255707
	abnormal skin condition	J:255707
	alopecia	J:255707
	diluted coat color	J:255707
	enlarged spinous cells	J:255707
	skin lesions	J:255707
	thick epidermis	J:255707
	thick epidermis stratum spinosum	J:255707

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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