About   Help   FAQ
GO Annotations Graph
Symbol
Name
ID
Jak3
Janus kinase 3
MGI:99928

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0004715non-membrane spanning protein tyrosine kinase activityIBAJ:161428
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:62510
Molecular FunctionGO:0004672protein kinase activityIEAJ:72247
Molecular FunctionGO:0019903protein phosphatase bindingISOJ:164563
Molecular FunctionGO:0004713protein tyrosine kinase activityIDAJ:62510
Molecular FunctionGO:0004713protein tyrosine kinase activityIDAJ:19201
Molecular FunctionGO:0004713protein tyrosine kinase activityISOJ:155856
Molecular FunctionGO:0005102receptor bindingIBAJ:161428
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005856cytoskeletonIEAJ:72247
Cellular ComponentGO:0005829cytosolISOJ:155856
Cellular ComponentGO:0031234extrinsic component of cytoplasmic side of plasma membraneIBAJ:161428
Cellular ComponentGO:0005622intracellularICJ:62510
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0016020membraneIEAJ:72247
Biological ProcessGO:0002250adaptive immune responseIEAJ:60000
Biological ProcessGO:0030183B cell differentiationIMPJ:112031
Biological ProcessGO:0016477cell migrationIBAJ:161428
Biological ProcessGO:0071345cellular response to cytokine stimulusIMPJ:150450
Biological ProcessGO:0019221cytokine-mediated signaling pathwayIDAJ:19201
Biological ProcessGO:0019221cytokine-mediated signaling pathwayISOJ:155856
Biological ProcessGO:0007167enzyme linked receptor protein signaling pathwayIDAJ:19201
Biological ProcessGO:0002376immune system processIEAJ:60000
Biological ProcessGO:0045087innate immune responseIBAJ:161428
Biological ProcessGO:0035771interleukin-4-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0035556intracellular signal transductionIDAJ:19201
Biological ProcessGO:0048535lymph node developmentTASJ:60454
Biological ProcessGO:0002731negative regulation of dendritic cell cytokine productionIMPJ:123902
Biological ProcessGO:0045221negative regulation of FasL biosynthetic processIMPJ:112031
Biological ProcessGO:0032693negative regulation of interleukin-10 productionIMPJ:123902
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIMPJ:123902
Biological ProcessGO:0050868negative regulation of T cell activationIMPJ:112031
Biological ProcessGO:0045626negative regulation of T-helper 1 cell differentiationIMPJ:123902
Biological ProcessGO:0070244negative regulation of thymocyte apoptotic processIMPJ:106675
Biological ProcessGO:0038083peptidyl-tyrosine autophosphorylationIBAJ:161428
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationIDAJ:62510
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:0042104positive regulation of activated T cell proliferationISOJ:155856
Biological ProcessGO:0051928positive regulation of calcium ion transportISOJ:155856
Biological ProcessGO:0007204positive regulation of cytosolic calcium ion concentrationISOJ:155856
Biological ProcessGO:2000670positive regulation of dendritic cell apoptotic processIMPJ:123902
Biological ProcessGO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIMPJ:123902
Biological ProcessGO:0050778positive regulation of immune responseISOJ:155856
Biological ProcessGO:0042102positive regulation of T cell proliferationISOJ:155856
Biological ProcessGO:0042102positive regulation of T cell proliferationIBAJ:161428
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:98326
Biological ProcessGO:0046777protein autophosphorylationISOJ:155856
Biological ProcessGO:0006468protein phosphorylationIEAJ:72247
Biological ProcessGO:0070232regulation of T cell apoptotic processIMPJ:112031
Biological ProcessGO:0070672response to interleukin-15TASJ:172922
Biological ProcessGO:0070669response to interleukin-2TASJ:106675
Biological ProcessGO:0070670response to interleukin-4TASJ:172922
Biological ProcessGO:0070670response to interleukin-4ISOJ:164563
Biological ProcessGO:0071104response to interleukin-9TASJ:172922
Biological ProcessGO:0043029T cell homeostasisIMPJ:112031
Biological ProcessGO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIBAJ:161428
Biological ProcessGO:0042506tyrosine phosphorylation of Stat5 proteinISOJ:155856


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2022
MGI 6.21
The Jackson Laboratory