GO Annotations Graph

• Symbol: Jak3
• Name: Janus kinase 3
• ID: MGI:99928

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005126	cytokine receptor binding	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:19201
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295758
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295764
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983294
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983313
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983356
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007126
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007137
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009867
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0030183	B cell differentiation	IMP	J:112031
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071345	cellular response to cytokine stimulus	IMP	J:150450
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:19201
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	IDA	J:19201
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:19201
Biological Process	GO:0048535	lymph node development	TAS	J:60454
Biological Process	GO:0002731	negative regulation of dendritic cell cytokine production	IMP	J:123902
Biological Process	GO:0045221	negative regulation of FasL production	IMP	J:112031
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:123902
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:123902
Biological Process	GO:0050868	negative regulation of T cell activation	IMP	J:112031
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	IMP	J:123902
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP	J:106675
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	IMP	J:123902
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:123902
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:98326
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0070232	regulation of T cell apoptotic process	IMP	J:112031
Biological Process	GO:0070672	response to interleukin-15	TAS	J:172922
Biological Process	GO:0070669	response to interleukin-2	TAS	J:106675
Biological Process	GO:0070670	response to interleukin-4	TAS	J:172922
Biological Process	GO:0070670	response to interleukin-4	ISO	J:164563
Biological Process	GO:0071104	response to interleukin-9	TAS	J:172922
Biological Process	GO:0043029	T cell homeostasis	IMP	J:112031
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:98326