GO Annotations Graph

• Symbol: Prdx1
• Name: peroxiredoxin 1
• ID: MGI:99523

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016209	antioxidant activity	IEA	J:60000
Molecular Function	GO:0016209	antioxidant activity	IEA	J:72247
Molecular Function	GO:0020037	heme binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:183198
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0004601	peroxidase activity	ISO	J:73065
Molecular Function	GO:0051920	peroxiredoxin activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:183198
Molecular Function	GO:0008379	thioredoxin peroxidase activity	ISO	J:164563
Molecular Function	GO:0008379	thioredoxin peroxidase activity	IBA	J:265628
Molecular Function	GO:0140824	thioredoxin-dependent peroxiredoxin activity	IEA	J:72245
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868583
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0000791	euchromatin	ISO	J:155856
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005782	peroxisomal matrix	ISO	J:155856
Biological Process	GO:0045454	cell redox homeostasis	IBA	J:265628
Biological Process	GO:0033554	cellular response to stress	IBA	J:265628
Biological Process	GO:0034101	erythrocyte homeostasis	IMP	J:84677
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:84677
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IBA	J:265628
Biological Process	GO:0042744	hydrogen peroxide catabolic process	ISO	J:73065
Biological Process	GO:0045321	leukocyte activation	IBA	J:265628
Biological Process	GO:0030101	natural killer cell activation	ISO	J:164563
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IMP	J:84677
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	IMP	J:98374
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	IMP	J:116929
Biological Process	GO:0019430	removal of superoxide radicals	IBA	J:265628
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:116929
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:104078
Biological Process	GO:0006979	response to oxidative stress	IBA	J:265628
Biological Process	GO:0006979	response to oxidative stress	IDA	J:14699
Biological Process	GO:0006979	response to oxidative stress	IMP	J:98374
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:104078
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:103909
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:84677