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GO Annotations Graph
Symbol
Name
ID
Top2a
topoisomerase (DNA) II alpha
MGI:98790

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingISOJ:155856
Molecular FunctionGO:0003682chromatin bindingISOJ:164563
Molecular FunctionGO:0003682chromatin bindingISOJ:155856
Molecular FunctionGO:0003677DNA bindingISOJ:164563
Molecular FunctionGO:0008301DNA binding, bendingISOJ:164563
Molecular FunctionGO:0003916DNA topoisomerase activityISOJ:155856
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityIGIJ:110796
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityIGIJ:3098
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityIDAJ:3098
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityISOJ:155856
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityISOJ:164563
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityIDAJ:22850
Molecular FunctionGO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activityIDAJ:39389
Molecular FunctionGO:0008094DNA-dependent ATPase activityISOJ:164563
Molecular FunctionGO:0008144drug bindingISOJ:164563
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0042826histone deacetylase bindingISOJ:164563
Molecular FunctionGO:0016853isomerase activityIEAJ:60000
Molecular FunctionGO:0000287magnesium ion bindingISOJ:164563
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0044822poly(A) RNA bindingISOJ:164563
Molecular FunctionGO:0008022protein C-terminus bindingISOJ:164563
Molecular FunctionGO:0046982protein heterodimerization activityISOJ:164563
Molecular FunctionGO:0042803protein homodimerization activityISOJ:164563
Molecular FunctionGO:0005080protein kinase C bindingISOJ:164563
Molecular FunctionGO:0043565sequence-specific DNA bindingISOJ:155856
Molecular FunctionGO:0043566structure-specific DNA bindingISOJ:155856
Molecular FunctionGO:0043130ubiquitin bindingISOJ:164563
Cellular ComponentGO:0005814colocalizes_with
centriole
ISOJ:164563
Cellular ComponentGO:0000793condensed chromosomeIDAJ:74600
Cellular ComponentGO:0009330DNA topoisomerase complex (ATP-hydrolyzing)ISOJ:164563
Cellular ComponentGO:0009330DNA topoisomerase complex (ATP-hydrolyzing)ISOJ:155856
Cellular ComponentGO:0000228colocalizes_with
nuclear chromosome
ISOJ:164563
Cellular ComponentGO:0005730nucleolusISOJ:155856
Cellular ComponentGO:0005730nucleolusIDAJ:74600
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:39389
Cellular ComponentGO:0005634nucleusIDAJ:42077
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0043234protein complexISOJ:164563
Biological ProcessGO:0030263apoptotic chromosome condensationISOJ:164563
Biological ProcessGO:0006974cellular response to DNA damage stimulusISOJ:164563
Biological ProcessGO:0030261chromosome condensationIMPJ:74620
Biological ProcessGO:0007059chromosome segregationIDAJ:22850
Biological ProcessGO:0007059chromosome segregationISOJ:164563
Biological ProcessGO:0007059chromosome segregationIMPJ:74620
Biological ProcessGO:0006266DNA ligationISOJ:164563
Biological ProcessGO:0006259DNA metabolic processIEAJ:72247
Biological ProcessGO:0006265DNA topological changeISOJ:164563
Biological ProcessGO:0006265DNA topological changeIDAJ:42077
Biological ProcessGO:0006265DNA topological changeIDAJ:3098
Biological ProcessGO:0006265DNA topological changeISOJ:155856
Biological ProcessGO:0040016embryonic cleavageIMPJ:74620
Biological ProcessGO:0002244hematopoietic progenitor cell differentiationIMPJ:202604
Biological ProcessGO:0044774mitotic DNA integrity checkpointIBAJ:161428
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:164563
Biological ProcessGO:0045870positive regulation of single stranded viral RNA replication via double stranded DNA intermediateISOJ:164563
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIMPJ:1777
Biological ProcessGO:0045070positive regulation of viral genome replicationISOJ:164563
Biological ProcessGO:0042752regulation of circadian rhythmIMPJ:217257
Biological ProcessGO:0000712resolution of meiotic recombination intermediatesIBAJ:161428
Biological ProcessGO:0048511rhythmic processIEAJ:60000
Biological ProcessGO:0000819sister chromatid segregationIBAJ:161428


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory