About   Help   FAQ
GO Annotations Graph
Symbol
Name
ID
Scn5a
sodium channel, voltage-gated, type V, alpha
MGI:98251

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0030506ankyrin bindingISOJ:155856
Molecular FunctionGO:0030506ankyrin bindingISOJ:164563
Molecular FunctionGO:0005516calmodulin bindingISOJ:164563
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0017134fibroblast growth factor bindingISOJ:164563
Molecular FunctionGO:0017134fibroblast growth factor bindingISOJ:155856
Molecular FunctionGO:0005216ion channel activityIEAJ:72247
Molecular FunctionGO:0044325ion channel bindingISOJ:164563
Molecular FunctionGO:0050998nitric-oxide synthase bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:184957
Molecular FunctionGO:0005515protein bindingIPIJ:93341
Molecular FunctionGO:0005515protein bindingIPIJ:187546
Molecular FunctionGO:0005515protein bindingIPIJ:221558
Molecular FunctionGO:0005515protein bindingIPIJ:184959
Molecular FunctionGO:0019904protein domain specific bindingISOJ:164563
Molecular FunctionGO:0019901protein kinase bindingISOJ:164563
Molecular FunctionGO:0097110scaffold protein bindingISOJ:164563
Molecular FunctionGO:0097110scaffold protein bindingIPIJ:198910
Molecular FunctionGO:0005272sodium channel activityIEAJ:60000
Molecular FunctionGO:0031625ubiquitin protein ligase bindingISOJ:164563
Molecular FunctionGO:0005244voltage-gated ion channel activityIEAJ:60000
Molecular FunctionGO:0005248voltage-gated sodium channel activityISOJ:164563
Molecular FunctionGO:0005248voltage-gated sodium channel activityIDAJ:108205
Molecular FunctionGO:0086060voltage-gated sodium channel activity involved in AV node cell action potentialISOJ:164563
Molecular FunctionGO:0086061voltage-gated sodium channel activity involved in bundle of His cell action potentialISOJ:164563
Molecular FunctionGO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potentialIMPJ:76331
Molecular FunctionGO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potentialISOJ:164563
Molecular FunctionGO:0086062voltage-gated sodium channel activity involved in Purkinje myocyte action potentialISOJ:164563
Molecular FunctionGO:0086063voltage-gated sodium channel activity involved in SA node cell action potentialISOJ:164563
Molecular FunctionGO:0086063voltage-gated sodium channel activity involved in SA node cell action potentialIMPJ:151611
Cellular ComponentGO:0005901caveolaISOJ:164563
Cellular ComponentGO:0009986cell surfaceIDAJ:127606
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0016021integral component of membraneISOJ:164563
Cellular ComponentGO:0014704intercalated discISOJ:164563
Cellular ComponentGO:0014704intercalated discIDAJ:161910
Cellular ComponentGO:0014704intercalated discIDAJ:184959
Cellular ComponentGO:0014704intercalated discISOJ:155856
Cellular ComponentGO:0014704intercalated discIDAJ:93341
Cellular ComponentGO:0014704intercalated discIDAJ:127606
Cellular ComponentGO:0014704intercalated discIDAJ:109097
Cellular ComponentGO:0014704intercalated discIDAJ:165334
Cellular ComponentGO:0005622intracellularISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:72247
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0005886plasma membraneIDAJ:109097
Cellular ComponentGO:0042383sarcolemmaISOJ:164563
Cellular ComponentGO:0034706sodium channel complexIPIJ:93341
Cellular ComponentGO:0030315T-tubuleISOJ:164563
Cellular ComponentGO:0030315T-tubuleIDAJ:109097
Cellular ComponentGO:0030315T-tubuleISOJ:155856
Cellular ComponentGO:0030315T-tubuleIDAJ:161910
Cellular ComponentGO:0001518voltage-gated sodium channel complexICJ:108205
Cellular ComponentGO:0001518voltage-gated sodium channel complexISOJ:164563
Cellular ComponentGO:0030018Z discISOJ:164563
Biological ProcessGO:0086016AV node cell action potentialISOJ:164563
Biological ProcessGO:0086067AV node cell to bundle of His cell communicationISOJ:164563
Biological ProcessGO:0086043bundle of His cell action potentialISOJ:164563
Biological ProcessGO:0086002cardiac muscle cell action potential involved in contractionISOJ:164563
Biological ProcessGO:0060048cardiac muscle contractionISOJ:164563
Biological ProcessGO:0003231cardiac ventricle developmentIMPJ:76331
Biological ProcessGO:0071277cellular response to calcium ionISOJ:164563
Biological ProcessGO:0006811ion transportIEAJ:60000
Biological ProcessGO:0006811ion transportIEAJ:72247
Biological ProcessGO:0051899membrane depolarizationISOJ:164563
Biological ProcessGO:0086010membrane depolarization during action potentialISOJ:164563
Biological ProcessGO:0086045membrane depolarization during AV node cell action potentialISOJ:164563
Biological ProcessGO:0086048membrane depolarization during bundle of His cell action potentialISOJ:164563
Biological ProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialISOJ:164563
Biological ProcessGO:0086047membrane depolarization during Purkinje myocyte cell action potentialISOJ:164563
Biological ProcessGO:0086046membrane depolarization during SA node cell action potentialISOJ:164563
Biological ProcessGO:0019228neuronal action potentialIBAJ:161428
Biological ProcessGO:0045760positive regulation of action potentialISOJ:155856
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationISOJ:155856
Biological ProcessGO:0010460positive regulation of heart rateISOJ:155856
Biological ProcessGO:0010765positive regulation of sodium ion transportISOJ:164563
Biological ProcessGO:0060371regulation of atrial cardiac muscle cell membrane depolarizationISOJ:164563
Biological ProcessGO:0060372regulation of atrial cardiac muscle cell membrane repolarizationISOJ:164563
Biological ProcessGO:0086004regulation of cardiac muscle cell contractionISOJ:164563
Biological ProcessGO:0086004regulation of cardiac muscle cell contractionIMPJ:116845
Biological ProcessGO:0002027regulation of heart rateISOJ:164563
Biological ProcessGO:0086091regulation of heart rate by cardiac conductionIMPJ:151611
Biological ProcessGO:0086091regulation of heart rate by cardiac conductionIMPJ:109689
Biological ProcessGO:0086091regulation of heart rate by cardiac conductionISOJ:164563
Biological ProcessGO:0086091regulation of heart rate by cardiac conductionIMPJ:116845
Biological ProcessGO:0086091regulation of heart rate by cardiac conductionIMPJ:76331
Biological ProcessGO:0034765regulation of ion transmembrane transportIEAJ:60000
Biological ProcessGO:1902305regulation of sodium ion transmembrane transportISOJ:164563
Biological ProcessGO:0060373regulation of ventricular cardiac muscle cell membrane depolarizationISOJ:164563
Biological ProcessGO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationISOJ:164563
Biological ProcessGO:0014894response to denervation involved in regulation of muscle adaptationISOJ:155856
Biological ProcessGO:0014070response to organic cyclic compoundIMPJ:169955
Biological ProcessGO:0086015SA node cell action potentialISOJ:164563
Biological ProcessGO:0035725sodium ion transmembrane transportISOJ:164563
Biological ProcessGO:0035725sodium ion transmembrane transportISOJ:155856
Biological ProcessGO:0006814sodium ion transportISOJ:164563
Biological ProcessGO:0006814sodium ion transportIDAJ:108205
Biological ProcessGO:0055085transmembrane transportIEAJ:72247
Biological ProcessGO:0006810transportIEAJ:60000
Biological ProcessGO:0086005ventricular cardiac muscle cell action potentialISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory