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GO Annotations Graph
Symbol
Name
ID
Ptpn2
protein tyrosine phosphatase, non-receptor type 2
MGI:97806

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0005178integrin bindingISOJ:164563
Molecular FunctionGO:0004726non-membrane spanning protein tyrosine phosphatase activityISOJ:155856
Molecular FunctionGO:0016791phosphatase activityIEAJ:72247
Molecular FunctionGO:0004721phosphoprotein phosphatase activityIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:197519
Molecular FunctionGO:0005515protein bindingIPIJ:109622
Molecular FunctionGO:0019901protein kinase bindingISOJ:164563
Molecular FunctionGO:0004725protein tyrosine phosphatase activityISOJ:164563
Molecular FunctionGO:0004725protein tyrosine phosphatase activityIMPJ:88185
Molecular FunctionGO:0030971receptor tyrosine kinase bindingISOJ:164563
Molecular FunctionGO:0019905syntaxin bindingISOJ:164563
Cellular ComponentGO:0005737cytoplasmIEAJ:60000
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0005793endoplasmic reticulum-Golgi intermediate compartmentISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005634nucleusIDAJ:219081
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0005886colocalizes_with
plasma membrane
ISOJ:164563
Biological ProcessGO:0030183B cell differentiationIMPJ:42595
Biological ProcessGO:0016311dephosphorylationIEAJ:72247
Biological ProcessGO:0030218erythrocyte differentiationIMPJ:42595
Biological ProcessGO:0042593glucose homeostasisIMPJ:169644
Biological ProcessGO:0008286insulin receptor signaling pathwayIMPJ:96001
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:164563
Biological ProcessGO:0050922negative regulation of chemotaxisIMPJ:88185
Biological ProcessGO:0042059negative regulation of epidermal growth factor receptor signaling pathwayISOJ:164563
Biological ProcessGO:0070373negative regulation of ERK1 and ERK2 cascadeIMPJ:96360
Biological ProcessGO:0050728negative regulation of inflammatory responseIMPJ:90541
Biological ProcessGO:0046627negative regulation of insulin receptor signaling pathwayIMPJ:196641
Biological ProcessGO:0046627negative regulation of insulin receptor signaling pathwayIMPJ:169644
Biological ProcessGO:0060336negative regulation of interferon-gamma-mediated signaling pathwayIMPJ:197518
Biological ProcessGO:1902206negative regulation of interleukin-2-mediated signaling pathwayISOJ:164563
Biological ProcessGO:1902206negative regulation of interleukin-2-mediated signaling pathwayIMPJ:115366
Biological ProcessGO:1902215negative regulation of interleukin-4-mediated signaling pathwayISOJ:164563
Biological ProcessGO:1902215negative regulation of interleukin-4-mediated signaling pathwayIMPJ:197516
Biological ProcessGO:0070104negative regulation of interleukin-6-mediated signaling pathwayIMPJ:169644
Biological ProcessGO:0070104negative regulation of interleukin-6-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0010888negative regulation of lipid storageIMPJ:169644
Biological ProcessGO:1902227negative regulation of macrophage colony-stimulating factor signaling pathwayIMPJ:109622
Biological ProcessGO:0045650negative regulation of macrophage differentiationIMPJ:109622
Biological ProcessGO:2000587negative regulation of platelet-derived growth factor receptor-beta signaling pathwayIMPJ:88185
Biological ProcessGO:1902233negative regulation of positive thymic T cell selectionIMPJ:184426
Biological ProcessGO:1902212negative regulation of prolactin signaling pathwayIMPJ:197519
Biological ProcessGO:0061099negative regulation of protein tyrosine kinase activityIMPJ:219081
Biological ProcessGO:0050860negative regulation of T cell receptor signaling pathwayIMPJ:184426
Biological ProcessGO:0010804negative regulation of tumor necrosis factor-mediated signaling pathwayIMPJ:96360
Biological ProcessGO:0060339negative regulation of type I interferon-mediated signaling pathwayISOJ:164563
Biological ProcessGO:0060339negative regulation of type I interferon-mediated signaling pathwayIMPJ:115366
Biological ProcessGO:0060339negative regulation of type I interferon-mediated signaling pathwayIMPJ:197518
Biological ProcessGO:0042518negative regulation of tyrosine phosphorylation of Stat3 proteinISOJ:164563
Biological ProcessGO:0042524negative regulation of tyrosine phosphorylation of Stat5 proteinIMPJ:197519
Biological ProcessGO:0042527negative regulation of tyrosine phosphorylation of Stat6 proteinISOJ:164563
Biological ProcessGO:0042527negative regulation of tyrosine phosphorylation of Stat6 proteinIMPJ:197516
Biological ProcessGO:0035335peptidyl-tyrosine dephosphorylationISOJ:164563
Biological ProcessGO:0035335peptidyl-tyrosine dephosphorylationIMPJ:88185
Biological ProcessGO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayIMPJ:219081
Biological ProcessGO:0045722positive regulation of gluconeogenesisIMPJ:169644
Biological ProcessGO:1903899positive regulation of PERK-mediated unfolded protein responseIMPJ:219081
Biological ProcessGO:0006470protein dephosphorylationIMPJ:96001
Biological ProcessGO:1902202regulation of hepatocyte growth factor receptor signaling pathwayISOJ:164563
Biological ProcessGO:0030217T cell differentiationIMPJ:42595


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory