GO Annotations Graph

• Symbol: Prkaca
• Name: protein kinase, cAMP dependent, catalytic, alpha
• ID: MGI:97592

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IEA	J:72245
Molecular Function	GO:0005524	ATP binding	IMP	J:116402
Molecular Function	GO:0005524	ATP binding	IDA	J:240313
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	ISO	J:155856
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	TAS	Reactome:R-MMU-164055
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	TAS	Reactome:R-MMU-164136
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IBA	J:265628
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IDA	J:208561
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IDA	J:249507
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IDA	J:79888
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	ISO	J:135493
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IDA	J:331261
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IDA	J:331261
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IMP	J:103418
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:240313
Molecular Function	GO:0030145	manganese ion binding	IMP	J:116402
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:135493
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019211	phosphatase activator activity	IDA	J:331261
Molecular Function	GO:0019211	phosphatase activator activity	IDA	J:331261
Molecular Function	GO:0019211	phosphatase activator activity	IMP	J:103418
Molecular Function	GO:0005515	protein binding	IPI	J:206832
Molecular Function	GO:0005515	protein binding	IPI	J:245390
Molecular Function	GO:0005515	protein binding	IPI	J:245390
Molecular Function	GO:0005515	protein binding	IPI	J:292521
Molecular Function	GO:0005515	protein binding	IPI	J:245389
Molecular Function	GO:0005515	protein binding	IPI	J:245387
Molecular Function	GO:0005515	protein binding	IPI	J:116402
Molecular Function	GO:0005515	protein binding	IPI	J:248266
Molecular Function	GO:0005515	protein binding	IPI	J:79888
Molecular Function	GO:0005515	protein binding	IPI	J:245376
Molecular Function	GO:0005515	protein binding	IPI	J:296128
Molecular Function	GO:0005515	protein binding	IPI	J:245325
Molecular Function	GO:0005515	protein binding	IPI	J:172115
Molecular Function	GO:0005515	protein binding	IPI	J:175121
Molecular Function	GO:0005515	protein binding	IPI	J:236944
Molecular Function	GO:0005515	protein binding	IPI	J:89378
Molecular Function	GO:0005515	protein binding	IPI	J:265193
Molecular Function	GO:0005515	protein binding	IPI	J:85083
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:240313
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	IPI	J:116402
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:164563
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:164563
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	IBA	J:265628
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	IPI	J:265193
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:93130
Molecular Function	GO:0004672	protein kinase activity	IDA	J:128382
Molecular Function	GO:0004672	protein kinase activity	IDA	J:145388
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:240310
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:259134
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:240308
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-163422
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-5610710
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-NUL-5610740
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-NUL-9615367
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:135400
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	ISO	J:199676
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0001669	acrosomal vesicle	IDA	J:236944
Cellular Component	GO:0005930	axoneme	ISO	J:164563
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	ISO	J:164563
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	ISO	J:155856
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	IMP	J:116402
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0097546	ciliary base	IDA	J:181006
Cellular Component	GO:0097546	ciliary base	IDA	J:181006
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:41726
Cellular Component	GO:0005737	cytoplasm	IDA	J:78010
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-163422
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-164055
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5610710
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9010662
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610740
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:331262
Cellular Component	GO:0043197	dendritic spine	IDA	J:157360
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:96807
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:96807
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:85083
Cellular Component	GO:0031514	motile cilium	IEA	J:60000
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:35122
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-164136
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9005848
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9005872
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9615367
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:41726
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:116899
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	IDA	J:96807
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0036126	sperm flagellum	IDA	J:236944
Cellular Component	GO:0097225	sperm midpiece	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:208561
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:249507
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:328576
Biological Process	GO:0070417	cellular response to cold	IMP	J:276211
Biological Process	GO:0071377	cellular response to glucagon stimulus	IGI	J:292566
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	IMP	J:152384
Biological Process	GO:0001707	mesoderm formation	IGI	J:78010
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:96807
Biological Process	GO:0006397	mRNA processing	ISO	J:164563
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	IDA	J:331261
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	IMP	J:103418
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	ISO	J:155856
Biological Process	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI	J:181006
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:135493
Biological Process	GO:0001843	neural tube closure	IGI	J:181006
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:240310
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:240308
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:135400
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:135400
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IDA	J:331261
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:249507
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:328576
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:208561
Biological Process	GO:0046827	positive regulation of protein export from nucleus	IMP	J:113403
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	EXP	J:96807
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:96807
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:128382
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:132389
Biological Process	GO:0006611	protein export from nucleus	IDA	J:142024
Biological Process	GO:0006611	protein export from nucleus	ISO	J:135493
Biological Process	GO:0006611	protein export from nucleus	IMP	J:113403
Biological Process	GO:0006611	protein export from nucleus	IMP	J:113403
Biological Process	GO:0010737	protein kinase A signaling	IBA	J:265628
Biological Process	GO:0010737	protein kinase A signaling	ISO	J:135493
Biological Process	GO:1990044	protein localization to lipid droplet	IMP	J:276211
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:145388
Biological Process	GO:0006468	protein phosphorylation	IDA	J:132389
Biological Process	GO:0006468	protein phosphorylation	IDA	J:41726
Biological Process	GO:0006468	protein phosphorylation	IDA	J:145182
Biological Process	GO:0006468	protein phosphorylation	IDA	J:128382
Biological Process	GO:0006468	protein phosphorylation	IDA	J:93130
Biological Process	GO:0006468	protein phosphorylation	IDA	J:107249
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:180569
Biological Process	GO:0043457	regulation of cellular respiration	ISO	J:155856
Biological Process	GO:0045667	regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0070613	regulation of protein processing	IGI	J:181006
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0048240	sperm capacitation	IDA	J:152257
Biological Process	GO:0048792	spontaneous exocytosis of neurotransmitter	ISO	J:155856