GO Annotations Graph

• Symbol: Pcsk1
• Name: proprotein convertase subtilisin/kexin type 1
• ID: MGI:97511

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:139345
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:248247
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0004252	serine-type endopeptidase activity	IDA	J:131459
Molecular Function	GO:0004252	serine-type endopeptidase activity	TAS	Reactome:R-MMU-216806
Molecular Function	GO:0004252	serine-type endopeptidase activity	TAS	Reactome:R-MMU-508205
Molecular Function	GO:0004252	serine-type endopeptidase activity	TAS	Reactome:R-MMU-508217
Molecular Function	GO:0004252	serine-type endopeptidase activity	TAS	Reactome:R-MMU-508227
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004252	serine-type endopeptidase activity	IMP	J:78368
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005788	endoplasmic reticulum lumen	TAS	Reactome:R-MMU-181788
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:135486
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:78368
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-216806
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-508205
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-508217
Cellular Component	GO:0034774	secretory granule lumen	TAS	Reactome:R-MMU-508227
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Biological Process	GO:0030070	insulin processing	IMP	J:78368
Biological Process	GO:0043043	peptide biosynthetic process	IDA	J:131459
Biological Process	GO:0016486	peptide hormone processing	IDA	J:139345
Biological Process	GO:0016486	peptide hormone processing	ISO	J:155856
Biological Process	GO:0016486	peptide hormone processing	IDA	J:131459
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:155856
Biological Process	GO:0016540	protein autoprocessing	ISO	J:155856
Biological Process	GO:0016485	protein processing	IDA	J:139345
Biological Process	GO:0016485	protein processing	ISO	J:155856
Biological Process	GO:0016485	protein processing	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247