Nodal GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nodal
nodal growth differentiation factor
MGI:97359

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:183227
Molecular Function	GO:0005515	protein binding	IPI	J:90108
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:183227
Molecular Function	GO:0070698	type I activin receptor binding	ISO	J:164563
Molecular Function	GO:0070698	type I activin receptor binding	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IDA	J:183227
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1181148
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1181347
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1225898
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-1181349
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	TAS	J:3969
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP	J:19211
Biological Process	GO:0009948	anterior/posterior axis specification	IMP	J:73506
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:93140
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:108576
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:108576
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:70006
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:90040
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:73506
Biological Process	GO:0048327	axial mesodermal cell fate specification	IMP	J:85863
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0007420	brain development	IMP	J:73506
Biological Process	GO:0030154	cell differentiation	IDA	J:70738
Biological Process	GO:0045165	cell fate commitment	IMP	J:84300
Biological Process	GO:0016477	cell migration	IMP	J:93140
Biological Process	GO:0042074	cell migration involved in gastrulation	IDA	J:90040
Biological Process	GO:0008283	cell population proliferation	IMP	J:90040
Biological Process	GO:0008283	cell population proliferation	IMP	J:90040
Biological Process	GO:0007368	determination of left/right symmetry	TAS	J:59280
Biological Process	GO:0007368	determination of left/right symmetry	IDA	J:82703
Biological Process	GO:0007368	determination of left/right symmetry	IGI	J:108576
Biological Process	GO:0007368	determination of left/right symmetry	IGI	J:93051
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:79098
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:79098
Biological Process	GO:0007368	determination of left/right symmetry	IDA	J:82311
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:73506
Biological Process	GO:0007368	determination of left/right symmetry	IGI	J:245906
Biological Process	GO:0055123	digestive system development	IMP	J:73506
Biological Process	GO:0048546	digestive tract morphogenesis	IMP	J:73506
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:73506
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:73506
Biological Process	GO:0009880	embryonic pattern specification	IMP	J:73506
Biological Process	GO:0001892	embryonic placenta development	IMP	J:70738
Biological Process	GO:0001892	embryonic placenta development	IMP	J:70738
Biological Process	GO:0060136	embryonic process involved in female pregnancy	IMP	J:70738
Biological Process	GO:0060136	embryonic process involved in female pregnancy	IMP	J:70738
Biological Process	GO:0007492	endoderm development	IMP	J:73506
Biological Process	GO:0035987	endodermal cell differentiation	ISO	J:164563
Biological Process	GO:0060802	epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification	IMP	J:85863
Biological Process	GO:0033505	floor plate morphogenesis	IMP	J:73506
Biological Process	GO:0048859	formation of anatomical boundary	IMP	J:73506
Biological Process	GO:0007369	gastrulation	IMP	J:85863
Biological Process	GO:0007369	gastrulation	IMP	J:73506
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:119211
Biological Process	GO:0007281	germ cell development	IMP	J:189072
Biological Process	GO:0007507	heart development	IMP	J:73506
Biological Process	GO:0001947	heart looping	IGI	J:108576
Biological Process	GO:0001701	in utero embryonic development	IMP	J:94135
Biological Process	GO:0001701	in utero embryonic development	IMP	J:73506
Biological Process	GO:0002085	inhibition of neuroepithelial cell differentiation	IMP	J:110605
Biological Process	GO:0060460	left lung morphogenesis	IMP	J:73506
Biological Process	GO:0001889	liver development	IMP	J:73506
Biological Process	GO:0030324	lung development	IMP	J:73506
Biological Process	GO:0001893	maternal placenta development	IMP	J:185829
Biological Process	GO:0060137	maternal process involved in parturition	IMP	J:185829
Biological Process	GO:0048382	mesendoderm development	ISO	J:164563
Biological Process	GO:0048382	mesendoderm development	IMP	J:73506
Biological Process	GO:0048382	mesendoderm development	IMP	J:85863
Biological Process	GO:0001707	mesoderm formation	TAS	J:3969
Biological Process	GO:0001707	mesoderm formation	IMP	J:73506
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010721	negative regulation of cell development	IMP	J:189072
Biological Process	GO:0045596	negative regulation of cell differentiation	IDA	J:70738
Biological Process	GO:1901383	negative regulation of chorionic trophoblast cell proliferation	ISO	J:164563
Biological Process	GO:2000242	negative regulation of reproductive process	IMP	J:189072
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:70738
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:70738
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:70738
Biological Process	GO:1901164	negative regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:73506
Biological Process	GO:0001842	neural fold formation	IMP	J:73506
Biological Process	GO:0038092	nodal signaling pathway	IMP	J:183227
Biological Process	GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	IMP	J:182383
Biological Process	GO:0001890	placenta development	ISO	J:164563
Biological Process	GO:0010085	polarity specification of proximal/distal axis	IMP	J:85863
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:186031
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:90040
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:182383
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0090009	primitive streak formation	IGI	J:171680
Biological Process	GO:0010470	regulation of gastrulation	IGI	J:157256
Biological Process	GO:0010470	regulation of gastrulation	IGI	J:157256
Biological Process	GO:0009966	regulation of signal transduction	IDA	J:127541
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0060395	SMAD protein signal transduction	IDA	J:45399
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:93446
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:110605
Biological Process	GO:0019827	stem cell population maintenance	IGI	J:93446
Biological Process	GO:0048729	tissue morphogenesis	IMP	J:73506
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISA	J:3969
Biological Process	GO:0090010	transforming growth factor beta receptor signaling pathway involved in primitive streak formation	IMP	J:85863
Biological Process	GO:0001829	trophectodermal cell differentiation	IDA	J:70738
Biological Process	GO:0001831	trophectodermal cellular morphogenesis	IMP	J:70738
Biological Process	GO:0001831	trophectodermal cellular morphogenesis	IMP	J:70738
Biological Process	GO:0001944	vasculature development	IMP	J:73506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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