GO Annotations Graph

• Symbol: Mdm2
• Name: transformed mouse 3T3 cell double minute 2
• ID: MGI:96952

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008097	5S rRNA binding	ISO	J:164563
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016874	ligase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0061663	NEDD8 ligase activity	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	IPI	J:170216
Molecular Function	GO:0002039	p53 binding	ISO	J:155856
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	IBA	J:265628
Molecular Function	GO:0002039	p53 binding	IPI	J:124168
Molecular Function	GO:0002039	p53 binding	IPI	J:96269
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:240382
Molecular Function	GO:0005515	protein binding	IPI	J:163623
Molecular Function	GO:0005515	protein binding	IPI	J:176251
Molecular Function	GO:0005515	protein binding	IPI	J:164200
Molecular Function	GO:0005515	protein binding	IPI	J:265621
Molecular Function	GO:0005515	protein binding	IPI	J:187617
Molecular Function	GO:0005515	protein binding	IPI	J:241062
Molecular Function	GO:0005515	protein binding	IPI	J:170004
Molecular Function	GO:0005515	protein binding	IPI	J:126004
Molecular Function	GO:0005515	protein binding	IPI	J:133357
Molecular Function	GO:0005515	protein binding	IPI	J:248554
Molecular Function	GO:0005515	protein binding	IPI	J:193326
Molecular Function	GO:0005515	protein binding	IPI	J:222100
Molecular Function	GO:0005515	protein binding	IPI	J:154692
Molecular Function	GO:0005515	protein binding	IPI	J:214218
Molecular Function	GO:0005515	protein binding	IPI	J:275141
Molecular Function	GO:0005515	protein binding	IPI	J:150816
Molecular Function	GO:0005515	protein binding	IPI	J:204457
Molecular Function	GO:0005515	protein binding	IPI	J:99711
Molecular Function	GO:0005515	protein binding	IPI	J:181102
Molecular Function	GO:0005515	protein binding	IPI	J:83418
Molecular Function	GO:0005515	protein binding	IPI	J:99711
Molecular Function	GO:0005515	protein binding	IPI	J:78409
Molecular Function	GO:0005515	protein binding	IPI	J:181102
Molecular Function	GO:0005515	protein binding	IPI	J:94174
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0033612	receptor serine/threonine kinase binding	ISO	J:155856
Molecular Function	GO:0043021	ribonucleoprotein complex binding	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:155856
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:78409
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:155856
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:124168
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:90021
Cellular Component	GO:0005737	cytoplasm	IDA	J:144707
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9768929
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:169789
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:72910
Cellular Component	GO:0005730	nucleolus	IDA	J:100984
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:100984
Cellular Component	GO:0005634	nucleus	IDA	J:72910
Cellular Component	GO:0005634	nucleus	IDA	J:181102
Cellular Component	GO:0005634	nucleus	IDA	J:90021
Cellular Component	GO:0005634	nucleus	IDA	J:85359
Cellular Component	GO:0005634	nucleus	IDA	J:144707
Cellular Component	GO:0005634	nucleus	IDA	J:79357
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IDA	J:275141
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0003283	atrial septum development	IGI	J:188490
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IGI	J:188490
Biological Process	GO:0001568	blood vessel development	IMP	J:188490
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:188490
Biological Process	GO:0060411	cardiac septum morphogenesis	IGI	J:188490
Biological Process	GO:0060411	cardiac septum morphogenesis	IGI	J:188490
Biological Process	GO:0007049	cell cycle	IBA	J:265628
Biological Process	GO:0007049	cell cycle	IGI	J:94174
Biological Process	GO:0072717	cellular response to actinomycin D	ISO	J:164563
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:164563
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO	J:164563
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:188490
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:188490
Biological Process	GO:0045184	establishment of protein localization	ISO	J:164563
Biological Process	GO:0072537	fibroblast activation	ISO	J:155856
Biological Process	GO:0007507	heart development	IMP	J:188490
Biological Process	GO:0007507	heart development	IGI	J:188490
Biological Process	GO:0007507	heart development	IGI	J:188490
Biological Process	GO:0003170	heart valve development	IGI	J:188490
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0010955	negative regulation of protein processing	ISO	J:155856
Biological Process	GO:1901797	negative regulation of signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045787	positive regulation of cell cycle	IGI	J:94174
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0051149	positive regulation of muscle cell differentiation	IMP	J:222127
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0046827	positive regulation of protein export from nucleus	ISO	J:155856
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:155856
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	IMP	J:188490
Biological Process	GO:0002027	regulation of heart rate	IGI	J:188490
Biological Process	GO:0042176	regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:1990785	response to water-immersion restraint stress	ISO	J:155856
Biological Process	GO:0007089	traversing start control point of mitotic cell cycle	IDA	J:83418
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:222127
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:78409
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:73065
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:124168
Biological Process	GO:0003281	ventricular septum development	IGI	J:188490