GO Annotations Graph

• Symbol: Anxa1
• Name: annexin A1
• ID: MGI:96819

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	ISO	J:164563
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	IBA	J:265628
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:164563
Molecular Function	GO:1990814	DNA/DNA annealing activity	ISO	J:155856
Molecular Function	GO:0036121	double-stranded DNA helicase activity	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity	ISO	J:164563
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity	ISO	J:155856
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity	IBA	J:265628
Molecular Function	GO:0004859	phospholipase inhibitor activity	IEA	J:72247
Molecular Function	GO:0005543	phospholipid binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:314093
Molecular Function	GO:0005515	protein binding	IPI	J:87169
Molecular Function	GO:0005515	protein binding	IPI	J:160150
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0003727	single-stranded RNA binding	ISO	J:155856
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:125876
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:142735
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0001533	cornified envelope	ISO	J:164563
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0005737	cytoplasm	IDA	J:142735
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5332993
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0031232	extrinsic component of external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0019898	extrinsic component of membrane	ISO	J:164563
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:142735
Cellular Component	GO:0042629	mast cell granule	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0031514	motile cilium	IDA	J:125876
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IMP	J:144209
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:87169
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0031532	actin cytoskeleton reorganization	IBA	J:265628
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0046632	alpha-beta T cell differentiation	IMP	J:169943
Biological Process	GO:0046632	alpha-beta T cell differentiation	IBA	J:265628
Biological Process	GO:0050482	arachidonic acid secretion	IBA	J:265628
Biological Process	GO:0050482	arachidonic acid secretion	IMP	J:83336
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	IMP	J:81498
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	ISO	J:164563
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	ISO	J:155856
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	IBA	J:265628
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IBA	J:265628
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IBA	J:265628
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:155856
Biological Process	GO:0032508	DNA duplex unwinding	IBA	J:265628
Biological Process	GO:0031018	endocrine pancreas development	IBA	J:265628
Biological Process	GO:0044849	estrous cycle	IBA	J:265628
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO	J:164563
Biological Process	GO:0042063	gliogenesis	IBA	J:265628
Biological Process	GO:0071621	granulocyte chemotaxis	ISO	J:164563
Biological Process	GO:0071621	granulocyte chemotaxis	IBA	J:265628
Biological Process	GO:0070365	hepatocyte differentiation	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:142735
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0030073	insulin secretion	ISO	J:155856
Biological Process	GO:0030073	insulin secretion	IBA	J:265628
Biological Process	GO:0030216	keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0030216	keratinocyte differentiation	IBA	J:265628
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0014839	myoblast migration involved in skeletal muscle regeneration	IDA	J:219177
Biological Process	GO:0014839	myoblast migration involved in skeletal muscle regeneration	IBA	J:265628
Biological Process	GO:0045920	negative regulation of exocytosis	ISO	J:164563
Biological Process	GO:0045920	negative regulation of exocytosis	IBA	J:265628
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:1900138	negative regulation of phospholipase A2 activity	ISO	J:155856
Biological Process	GO:1900138	negative regulation of phospholipase A2 activity	IBA	J:265628
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:155856
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	ISO	J:164563
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	IBA	J:265628
Biological Process	GO:0042119	neutrophil activation	ISO	J:164563
Biological Process	GO:0097350	neutrophil clearance	ISO	J:164563
Biological Process	GO:0097350	neutrophil clearance	IBA	J:265628
Biological Process	GO:0001780	neutrophil homeostasis	IMP	J:180001
Biological Process	GO:0001780	neutrophil homeostasis	ISO	J:164563
Biological Process	GO:0018149	peptide cross-linking	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IMP	J:81498
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IBA	J:265628
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IMP	J:83336
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IBA	J:265628
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	IMP	J:180001
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	IBA	J:265628
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	ISO	J:155856
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	IBA	J:265628
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IBA	J:265628
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	ISO	J:164563
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	IBA	J:265628
Biological Process	GO:0031340	positive regulation of vesicle fusion	ISO	J:164563
Biological Process	GO:0031340	positive regulation of vesicle fusion	IBA	J:265628
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0090303	positive regulation of wound healing	IBA	J:265628
Biological Process	GO:0070459	prolactin secretion	ISO	J:155856
Biological Process	GO:0070459	prolactin secretion	IBA	J:265628
Biological Process	GO:0030850	prostate gland development	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:83336
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IBA	J:265628
Biological Process	GO:0046883	regulation of hormone secretion	ISO	J:164563
Biological Process	GO:0046883	regulation of hormone secretion	IBA	J:265628
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:81498
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0032652	regulation of interleukin-1 production	IMP	J:81498
Biological Process	GO:0032652	regulation of interleukin-1 production	IBA	J:265628
Biological Process	GO:0002685	regulation of leukocyte migration	IMP	J:81498
Biological Process	GO:0002685	regulation of leukocyte migration	IBA	J:265628
Biological Process	GO:0032355	response to estradiol	IBA	J:265628
Biological Process	GO:0070555	response to interleukin-1	IBA	J:265628
Biological Process	GO:0043434	response to peptide hormone	IBA	J:265628
Biological Process	GO:0010165	response to X-ray	IBA	J:265628
Biological Process	GO:0051238	sequestering of metal ion	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IMP	J:83336