Kit GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Kit
KIT proto-oncogene receptor tyrosine kinase
MGI:96677

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	IPI	J:169801
Molecular Function	GO:0005515	protein binding	IPI	J:245391
Molecular Function	GO:0005515	protein binding	IPI	J:89937
Molecular Function	GO:0005515	protein binding	IPI	J:82566
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:10751
Molecular Function	GO:0005515	protein binding	IPI	J:76219
Molecular Function	GO:0005515	protein binding	IPI	J:178186
Molecular Function	GO:0005515	protein binding	IPI	J:64951
Molecular Function	GO:0005515	protein binding	IPI	J:116468
Molecular Function	GO:0005515	protein binding	IPI	J:82566
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	IPI	J:89937
Molecular Function	GO:0005020	stem cell factor receptor activity	IDA	J:62510
Molecular Function	GO:0005020	stem cell factor receptor activity	IDA	J:62510
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:43157
Cellular Component	GO:0009986	cell surface	IDA	J:41397
Cellular Component	GO:0005911	cell-cell junction	IDA	J:195630
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:145577
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:63425
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:144049
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:101855
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:132871
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84889
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84599
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:89706
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:174203
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:155686
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:84890
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:99189
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:103896
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1470014
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1524177
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0030183	B cell differentiation	IBA	J:265628
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	TAS	J:78328
Biological Process	GO:0008283	cell population proliferation	IGI	J:59248
Biological Process	GO:0008283	cell population proliferation	IGI	J:59248
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	IDA	J:180565
Biological Process	GO:0006935	chemotaxis	TAS	J:78328
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:62510
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:96391
Biological Process	GO:0048066	developmental pigmentation	IMP	J:133403
Biological Process	GO:0048066	developmental pigmentation	IGI	J:133403
Biological Process	GO:0048066	developmental pigmentation	IMP	J:133403
Biological Process	GO:0048066	developmental pigmentation	IMP	J:133403
Biological Process	GO:0048066	developmental pigmentation	IMP	J:92947
Biological Process	GO:0048565	digestive tract development	IMP	J:89602
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:137091
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:86513
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:163026
Biological Process	GO:0050673	epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:79128
Biological Process	GO:0030218	erythrocyte differentiation	TAS	J:110595
Biological Process	GO:0038162	erythropoietin-mediated signaling pathway	IMP	J:186063
Biological Process	GO:0038093	Fc receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007281	germ cell development	TAS	J:78328
Biological Process	GO:0008354	germ cell migration	ISO	J:155856
Biological Process	GO:0006687	glycosphingolipid metabolic process	IMP	J:137091
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IBA	J:265628
Biological Process	GO:0035701	hematopoietic stem cell migration	IMP	J:178186
Biological Process	GO:0030097	hemopoiesis	IMP	J:76219
Biological Process	GO:0002327	immature B cell differentiation	IMP	J:89602
Biological Process	GO:0006954	inflammatory response	IMP	J:136704
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:62510
Biological Process	GO:0038109	Kit signaling pathway	ISO	J:164563
Biological Process	GO:0038109	Kit signaling pathway	IBA	J:265628
Biological Process	GO:0030032	lamellipodium assembly	IDA	J:186077
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	IGI	J:27238
Biological Process	GO:0002551	mast cell chemotaxis	ISO	J:164563
Biological Process	GO:0043303	mast cell degranulation	ISO	J:164563
Biological Process	GO:0060374	mast cell differentiation	IMP	J:101685
Biological Process	GO:0060374	mast cell differentiation	IMP	J:89602
Biological Process	GO:0060374	mast cell differentiation	IMP	J:133499
Biological Process	GO:0070662	mast cell proliferation	IGI	J:59248
Biological Process	GO:0070662	mast cell proliferation	IGI	J:59248
Biological Process	GO:0035855	megakaryocyte development	IMP	J:89602
Biological Process	GO:0097326	melanocyte adhesion	IDA	J:186166
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:104585
Biological Process	GO:0097324	melanocyte migration	IMP	J:89602
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IGI	J:27238
Biological Process	GO:0051093	negative regulation of developmental process	IMP	J:137091
Biological Process	GO:0043069	negative regulation of programmed cell death	IMP	J:137091
Biological Process	GO:0043069	negative regulation of programmed cell death	IGI	J:86513
Biological Process	GO:2000242	negative regulation of reproductive process	IMP	J:137091
Biological Process	GO:0001541	ovarian follicle development	IMP	J:163026
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043473	pigmentation	IMP	J:89602
Biological Process	GO:0043473	pigmentation	IGI	J:59248
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1904343	positive regulation of colon smooth muscle contraction	ISO	J:155856
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	IMP	J:136704
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:137091
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IGI	J:59248
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IGI	J:59248
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	ISO	J:164563
Biological Process	GO:0070668	positive regulation of mast cell proliferation	IGI	J:59248
Biological Process	GO:0070668	positive regulation of mast cell proliferation	IGI	J:59248
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:155856
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	ISO	J:155856
Biological Process	GO:0120072	positive regulation of pyloric antrum smooth muscle contraction	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:1905065	positive regulation of vascular associated smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	IGI	J:86513
Biological Process	GO:0012501	programmed cell death	IGI	J:86513
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	TAS	J:78328
Biological Process	GO:0006468	protein phosphorylation	IDA	J:76219
Biological Process	GO:1904251	regulation of bile acid metabolic process	ISO	J:155856
Biological Process	GO:0008360	regulation of cell shape	IDA	J:186077
Biological Process	GO:0009314	response to radiation	IMP	J:84568
Biological Process	GO:0048103	somatic stem cell division	ISO	J:155856
Biological Process	GO:0035019	somatic stem cell population maintenance	ISO	J:155856
Biological Process	GO:0007286	spermatid development	IMP	J:137091
Biological Process	GO:0007283	spermatogenesis	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IMP	J:163026
Biological Process	GO:0048863	stem cell differentiation	IMP	J:147651
Biological Process	GO:0030217	T cell differentiation	IMP	J:79128
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0008542	visual learning	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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