GO Annotations Graph

• Symbol: Itga5
• Name: integrin alpha 5 (fibronectin receptor alpha)
• ID: MGI:96604

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Wed Mar 2 12:11:24 2016.

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	IPI	J:31981
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:84858
Molecular Function	GO:0005515	protein binding	IPI	J:222137
Molecular Function	GO:0005515	protein binding	IPI	J:84472
Cellular Component	GO:0009986	cell surface	IDA	J:16243
Cellular Component	GO:0009986	cell surface	IDA	J:193934
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005911	colocalizes_with cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:215661
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:215661
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:47279
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:125138
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	colocalizes_with focal adhesion	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:215661
Cellular Component	GO:0016021	integral component of membrane	IEA	J:60000
Cellular Component	GO:0008305	integrin complex	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:215661
Cellular Component	GO:0032587	colocalizes_with ruffle membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:84858
Biological Process	GO:0007155	cell adhesion	ISO	J:155856
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin	IMP	J:125138
Biological Process	GO:0031589	cell-substrate adhesion	ISO	J:164563
Biological Process	GO:0007044	cell-substrate junction assembly	IDA	J:84472
Biological Process	GO:0035987	endodermal cell differentiation	ISO	J:164563
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	J:125138
Biological Process	GO:0034113	heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0007159	leukocyte cell-cell adhesion	IMP	J:125138
Biological Process	GO:0007613	memory	IMP	J:84858
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0045765	regulation of angiogenesis	IGI	J:149995

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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