GO Annotations Graph

• Symbol: Il10
• Name: interleukin 10
• ID: MGI:96537

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IMP	J:91939
Molecular Function	GO:0005125	cytokine activity	IDA	J:88533
Molecular Function	GO:0005141	interleukin-10 receptor binding	ISO	J:155856
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:116616
Cellular Component	GO:0005615	extracellular space	IDA	J:91804
Cellular Component	GO:0005615	extracellular space	IDA	J:58383
Cellular Component	GO:0005615	extracellular space	IDA	J:117165
Cellular Component	GO:0005615	extracellular space	IDA	J:113450
Cellular Component	GO:0005615	extracellular space	IDA	J:63492
Cellular Component	GO:0005615	extracellular space	IDA	J:63500
Cellular Component	GO:0005615	extracellular space	IDA	J:208236
Cellular Component	GO:0005615	extracellular space	IDA	J:91939
Cellular Component	GO:0005615	extracellular space	IDA	J:147177
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	IMP	J:113180
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IDA	J:166840
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:173330
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:143745
Biological Process	GO:0002439	chronic inflammatory response to antigenic stimulus	IMP	J:131892
Biological Process	GO:0042742	defense response to bacterium	IDA	J:63492
Biological Process	GO:0042832	defense response to protozoan	IDA	J:143745
Biological Process	GO:0006955	immune response	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	ISO	J:40789
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:235312
Biological Process	GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus	IMP	J:131892
Biological Process	GO:0060302	negative regulation of cytokine activity	ISO	J:164563
Biological Process	GO:0001818	negative regulation of cytokine production	ISO	J:164563
Biological Process	GO:0001818	negative regulation of cytokine production	ISO	J:155856
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	IGI	J:235312
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	IGI	J:235312
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	IGI	J:176368
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:135247
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:91939
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0045347	negative regulation of MHC class II biosynthetic process	ISO	J:164563
Biological Process	GO:0030886	negative regulation of myeloid dendritic cell activation	IMP	J:91939
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:1904057	negative regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:131892
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:131892
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	IGI	J:235312
Biological Process	GO:0002904	positive regulation of B cell apoptotic process	ISO	J:40789
Biological Process	GO:0045787	positive regulation of cell cycle	IGI	J:235312
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IGI	J:235312
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	ISO	J:155856
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	IDA	J:88533
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:1900100	positive regulation of plasma cell differentiation	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	IMP	J:228825
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:90824
Biological Process	GO:0010468	regulation of gene expression	ISO	J:40789
Biological Process	GO:1903034	regulation of response to wounding	IMP	J:235312
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0050807	regulation of synapse organization	ISO	J:155856
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:164563
Biological Process	GO:0002237	response to molecule of bacterial origin	ISO	J:164563