GO Annotations Graph

• Symbol: Igfbp5
• Name: insulin-like growth factor binding protein 5
• ID: MGI:96440

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001968	fibronectin binding	IBA	J:265628
Molecular Function	GO:0001968	fibronectin binding	IDA	J:147385
Molecular Function	GO:0019838	growth factor binding	IEA	J:60000
Molecular Function	GO:0005520	insulin-like growth factor binding	ISO	J:155856
Molecular Function	GO:0005520	insulin-like growth factor binding	IPI	J:86296
Molecular Function	GO:0005520	insulin-like growth factor binding	IPI	J:86296
Molecular Function	GO:0031994	insulin-like growth factor I binding	ISO	J:164563
Molecular Function	GO:0031994	insulin-like growth factor I binding	TAS	J:89234
Molecular Function	GO:0031994	insulin-like growth factor I binding	IBA	J:265628
Molecular Function	GO:0031995	insulin-like growth factor II binding	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016942	insulin-like growth factor binding protein complex	IC	J:86942
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	ISO	J:164563
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	TAS	J:89234
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0007565	female pregnancy	IMP	J:89234
Biological Process	GO:0042593	glucose homeostasis	IMP	J:155311
Biological Process	GO:0042593	glucose homeostasis	IGI	J:112029
Biological Process	GO:0042593	glucose homeostasis	IGI	J:112029
Biological Process	GO:0042593	glucose homeostasis	IMP	J:155311
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:100688
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:100688
Biological Process	GO:0048286	lung alveolus development	IMP	J:89234
Biological Process	GO:0060056	mammary gland involution	IMP	J:122252
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0045926	negative regulation of growth	IMP	J:89234
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	IMP	J:100688
Biological Process	GO:1901862	negative regulation of muscle tissue development	IMP	J:89234
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IGI	J:146446
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IGI	J:146446
Biological Process	GO:1904205	negative regulation of skeletal muscle hypertrophy	IMP	J:89234
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IEP	J:143682
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	IGI	J:112029
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	IGI	J:112029
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:138783
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0001558	regulation of cell growth	IGI	J:112029
Biological Process	GO:0001558	regulation of cell growth	IGI	J:112029
Biological Process	GO:0040008	regulation of growth	IGI	J:112029
Biological Process	GO:0040008	regulation of growth	IGI	J:112029
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	TAS	J:89234
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:138783
Biological Process	GO:0051146	striated muscle cell differentiation	IMP	J:138783
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:138783
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:112029
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:112029