GO Annotations Graph

• Symbol: Htr2c
• Name: 5-hydroxytryptamine (serotonin) receptor 2C
• ID: MGI:96281

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	ISO	J:164563
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:155856
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IMP	J:174678
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:31112
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:73065
Molecular Function	GO:0001587	Gq/11-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:117972
Molecular Function	GO:0051378	serotonin binding	ISO	J:164563
Molecular Function	GO:0051378	serotonin binding	ISO	J:31112
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:73065
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007610	behavior	IEA	J:60000
Biological Process	GO:0001662	behavioral fear response	IMP	J:137308
Biological Process	GO:0035095	behavioral response to nicotine	ISO	J:155856
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0007631	feeding behavior	IMP	J:24339
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048016	inositol phosphate-mediated signaling	ISO	J:73065
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0007626	locomotory behavior	IEA	J:72247
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	ISO	J:155856
Biological Process	GO:0040013	negative regulation of locomotion	ISO	J:155856
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	IMP	J:174678
Biological Process	GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	ISO	J:155856
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IMP	J:174678
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:182833
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	ISO	J:155856
Biological Process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0032098	regulation of appetite	IMP	J:166702
Biological Process	GO:0043397	regulation of corticotropin-releasing hormone secretion	IMP	J:122977
Biological Process	GO:0043397	regulation of corticotropin-releasing hormone secretion	IMP	J:137308
Biological Process	GO:0031644	regulation of nervous system process	IMP	J:122977
Biological Process	GO:0031644	regulation of nervous system process	IMP	J:166702
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000