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GO Annotations Graph
Symbol
Name
ID
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0050662coenzyme bindingISOJ:164563
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:78952
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:101203
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:76988
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:1025
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:40819
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:101230
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:73910
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:86378
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityIDAJ:22362
Molecular FunctionGO:0042282hydroxymethylglutaryl-CoA reductase activityISOJ:155856
Molecular FunctionGO:0042282hydroxymethylglutaryl-CoA reductase activityISOJ:164563
Molecular FunctionGO:0050661NADP bindingIEAJ:72247
Molecular FunctionGO:0070402NADPH bindingISOJ:164563
Molecular FunctionGO:0016491oxidoreductase activityIEAJ:60000
Molecular FunctionGO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorIEAJ:72247
Molecular FunctionGO:0042803protein homodimerization activityISOJ:155856
Molecular FunctionGO:0051721protein phosphatase 2A bindingISOJ:155856
Cellular ComponentGO:0005783endoplasmic reticulumISOJ:164563
Cellular ComponentGO:0005789endoplasmic reticulum membraneIBAJ:161428
Cellular ComponentGO:0016021integral component of membraneIEAJ:72247
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0043231intracellular membrane-bounded organelleISOJ:155856
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005778peroxisomal membraneIBAJ:161428
Cellular ComponentGO:0005778peroxisomal membraneISOJ:164563
Biological ProcessGO:0006695cholesterol biosynthetic processISOJ:164563
Biological ProcessGO:0006695cholesterol biosynthetic processIDAJ:22362
Biological ProcessGO:0006695cholesterol biosynthetic processIDAJ:101230
Biological ProcessGO:0006695cholesterol biosynthetic processISOJ:155856
Biological ProcessGO:0006695cholesterol biosynthetic processIDAJ:76988
Biological ProcessGO:0008203cholesterol metabolic processIEAJ:60000
Biological ProcessGO:0015936coenzyme A metabolic processIEAJ:72247
Biological ProcessGO:0009790embryo developmentIMPJ:86378
Biological ProcessGO:0008299isoprenoid biosynthetic processISOJ:155856
Biological ProcessGO:0008299isoprenoid biosynthetic processIBAJ:161428
Biological ProcessGO:0006629lipid metabolic processIEAJ:60000
Biological ProcessGO:0043066negative regulation of apoptotic processISOJ:155856
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusISOJ:155856
Biological ProcessGO:0043407negative regulation of MAP kinase activityIGIJ:103961
Biological ProcessGO:0010664negative regulation of striated muscle cell apoptotic processISOJ:155856
Biological ProcessGO:0045908negative regulation of vasodilationISOJ:155856
Biological ProcessGO:0061045negative regulation of wound healingISOJ:155856
Biological ProcessGO:0055114oxidation-reduction processIEAJ:60000
Biological ProcessGO:0055114oxidation-reduction processIEAJ:72247
Biological ProcessGO:0010666positive regulation of cardiac muscle cell apoptotic processISOJ:155856
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:155856
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:155856
Biological ProcessGO:0048643positive regulation of skeletal muscle tissue developmentISOJ:155856
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationISOJ:155856
Biological ProcessGO:0032874positive regulation of stress-activated MAPK cascadeISOJ:155856
Biological ProcessGO:0051262protein tetramerizationISOJ:164563
Biological ProcessGO:0006694steroid biosynthetic processIEAJ:60000
Biological ProcessGO:0008202steroid metabolic processIEAJ:60000
Biological ProcessGO:0016126sterol biosynthetic processIEAJ:60000
Biological ProcessGO:0006743ubiquinone metabolic processISOJ:155856
Biological ProcessGO:0008542visual learningIGIJ:103961


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/02/2021
MGI 6.16
The Jackson Laboratory