GO Annotations Graph

• Symbol: Erbb3
• Name: erb-b2 receptor tyrosine kinase 3
• ID: MGI:95411

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0038132	neuregulin binding	ISO	J:164563
Molecular Function	GO:0038132	neuregulin binding	ISO	J:155856
Molecular Function	GO:0038132	neuregulin binding	IBA	J:265628
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:155856
Molecular Function	GO:0038131	neuregulin receptor activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:203534
Molecular Function	GO:0005515	protein binding	IPI	J:168371
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IDA	J:34905
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:317053
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:94401
Cellular Component	GO:0009925	basal plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0038143	ERBB3:ERBB2 complex	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:94401
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:317053
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0021545	cranial nerve development	IMP	J:43515
Biological Process	GO:0021545	cranial nerve development	IMP	J:43515
Biological Process	GO:0003197	endocardial cushion development	IMP	J:45302
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:34905
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:317053
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:43515
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:43515
Biological Process	GO:0051048	negative regulation of secretion	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	ISO	J:164563
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:43515
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:43515
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:45302
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	IGI	J:144171
Biological Process	GO:0055025	positive regulation of cardiac muscle tissue development	IMP	J:210551
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:210551
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:43515
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:43515
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:73065