Egfr GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Egfr
epidermal growth factor receptor
MGI:95294

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0048408	epidermal growth factor binding	ISO	J:155856
Molecular Function	GO:0048408	epidermal growth factor binding	IBA	J:265628
Molecular Function	GO:0048408	epidermal growth factor binding	IDA	J:3764
Molecular Function	GO:0005006	epidermal growth factor receptor activity	ISO	J:155856
Molecular Function	GO:0005006	epidermal growth factor receptor activity	ISO	J:164563
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IBA	J:265628
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IDA	J:70074
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IDA	J:26923
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IGI	J:127663
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IDA	J:177277
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IMP	J:138989
Molecular Function	GO:0005006	epidermal growth factor receptor activity	ISO	J:317649
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IDA	J:48234
Molecular Function	GO:0005006	epidermal growth factor receptor activity	ISO	J:318709
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IDA	J:77668
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IDA	J:88364
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IDA	J:83953
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:248209
Molecular Function	GO:0005515	protein binding	IPI	J:107114
Molecular Function	GO:0005515	protein binding	IPI	J:93419
Molecular Function	GO:0005515	protein binding	IPI	J:171209
Molecular Function	GO:0005515	protein binding	IPI	J:220697
Molecular Function	GO:0005515	protein binding	IPI	J:190126
Molecular Function	GO:0005515	protein binding	IPI	J:206889
Molecular Function	GO:0005515	protein binding	IPI	J:100216
Molecular Function	GO:0005515	protein binding	IPI	J:96642
Molecular Function	GO:0005515	protein binding	IPI	J:79952
Molecular Function	GO:0005515	protein binding	IPI	J:124946
Molecular Function	GO:0005515	protein binding	IPI	J:85708
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:317779
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:318706
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IDA	J:3764
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:26923
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IMP	J:193394
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IMP	J:277693
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IMP	J:204096
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:22281
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IMP	J:80421
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IGI	J:247650
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:319897
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:73065
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:23046
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:203527
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:58581
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:58581
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0097489	multivesicular body, internal vesicle lumen	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:168265
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:168265
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:256252
Cellular Component	GO:0005886	plasma membrane	IDA	J:70074
Cellular Component	GO:0005886	plasma membrane	IDA	J:26923
Cellular Component	GO:0005886	plasma membrane	IDA	J:177277
Cellular Component	GO:0005886	plasma membrane	IDA	J:26923
Cellular Component	GO:0005886	plasma membrane	IDA	J:317054
Cellular Component	GO:0005886	plasma membrane	IDA	J:256252
Cellular Component	GO:0005886	plasma membrane	ISO	J:316873
Cellular Component	GO:0005886	plasma membrane	IDA	J:22281
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IGI	J:247650
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	ISO	J:317649
Cellular Component	GO:0005886	plasma membrane	IDA	J:319897
Cellular Component	GO:0005886	plasma membrane	IDA	J:3764
Cellular Component	GO:0005886	plasma membrane	IDA	J:28214
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0048143	astrocyte activation	ISO	J:155856
Biological Process	GO:0000902	cell morphogenesis	IGI	J:128355
Biological Process	GO:0008283	cell population proliferation	IGI	J:138998
Biological Process	GO:0008283	cell population proliferation	IGI	J:138998
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:73065
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:186714
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:155856
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:34905
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0021795	cerebral cortex cell migration	IMP	J:26833
Biological Process	GO:0048546	digestive tract morphogenesis	IMP	J:26833
Biological Process	GO:0001892	embryonic placenta development	IMP	J:26833
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:26923
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:70074
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:26923
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:277693
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:193394
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:204096
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:80421
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:22281
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:47407
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:247650
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:34905
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:3764
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:317779
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:83700
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:128355
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:96642
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:73065
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:88364
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:28214
Biological Process	GO:0008544	epidermis development	IMP	J:26833
Biological Process	GO:0008544	epidermis development	IMP	J:26833
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:26833
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:177277
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:47407
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:34905
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:34905
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IMP	J:138989
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	ISO	J:317649
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:319897
Biological Process	GO:0061029	eyelid development in camera-type eye	IGI	J:38321
Biological Process	GO:0001942	hair follicle development	IMP	J:26833
Biological Process	GO:0001942	hair follicle development	IGI	J:38321
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0097421	liver regeneration	ISO	J:155856
Biological Process	GO:0010960	magnesium ion homeostasis	ISO	J:155856
Biological Process	GO:0060571	morphogenesis of an epithelial fold	IMP	J:26833
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:1905208	negative regulation of cardiocyte differentiation	ISO	J:164563
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0042698	ovulation cycle	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:138998
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:138998
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:28214
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:28214
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:88364
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0045739	positive regulation of DNA repair	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IBA	J:265628
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:26833
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:168265
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0070257	positive regulation of mucus secretion	ISO	J:155856
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:1902722	positive regulation of prolactin secretion	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900020	positive regulation of protein kinase C activity	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:92782
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:74510
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0046328	regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IMP	J:77668
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0070141	response to UV-A	ISO	J:164563
Biological Process	GO:0007435	salivary gland morphogenesis	IMP	J:69420
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IDA	J:77668
Biological Process	GO:0006412	translation	ISO	J:155856
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042060	wound healing	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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