GO Annotations Graph

• Symbol: Ccne1
• Name: cyclin E1
• ID: MGI:88316

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	IBA	J:265628
Molecular Function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	IDA	J:85481
Molecular Function	GO:0016301	kinase activity	IDA	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:155178
Molecular Function	GO:0005515	protein binding	IPI	J:124678
Molecular Function	GO:0005515	protein binding	IPI	J:158603
Molecular Function	GO:0005515	protein binding	IPI	J:57761
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0005515	protein binding	IPI	J:158674
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IPI	J:105978
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005813	centrosome	ISO	J:155856
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0097134	cyclin E1-CDK2 complex	IBA	J:265628
Cellular Component	GO:0097134	cyclin E1-CDK2 complex	IDA	J:24521
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:57761
Cellular Component	GO:0005634	nucleus	ISO	J:101015
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0070192	chromosome organization involved in meiotic cell cycle	IGI	J:226665
Biological Process	GO:0006270	DNA replication initiation	IMP	J:85224
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IGI	J:226665
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:26103
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:155856
Biological Process	GO:1902462	positive regulation of mesenchymal stem cell proliferation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:78410
Biological Process	GO:0006468	protein phosphorylation	ISS	J:57761
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:85481
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Biological Process	GO:0032880	regulation of protein localization	IGI	J:226665
Biological Process	GO:0000723	telomere maintenance	IGI	J:226665
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:142037