Bmp2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Bmp2
bone morphogenetic protein 2
MGI:88177

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070700	BMP receptor binding	IBA	J:265628
Molecular Function	GO:0070700	BMP receptor binding	ISO	J:22224
Molecular Function	GO:0039706	co-receptor binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IMP	J:110615
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	TAS	J:36213
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0019211	phosphatase activator activity	ISO	J:41877
Molecular Function	GO:0005515	protein binding	IPI	J:203960
Molecular Function	GO:0005515	protein binding	IPI	J:124617
Molecular Function	GO:0005515	protein binding	IPI	J:179857
Molecular Function	GO:0005515	protein binding	IPI	J:117639
Molecular Function	GO:0005515	protein binding	IPI	J:183590
Molecular Function	GO:0005515	protein binding	IPI	J:84799
Molecular Function	GO:0005515	protein binding	IPI	J:87049
Molecular Function	GO:0005515	protein binding	IPI	J:101046
Molecular Function	GO:0005515	protein binding	IPI	J:86665
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:299402
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:299317
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Cellular Component	GO:0070724	BMP receptor complex	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IDA	J:299317
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:90643
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:299402
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0036305	ameloblast differentiation	IDA	J:94518
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:36213
Biological Process	GO:0003176	aortic valve development	IMP	J:110615
Biological Process	GO:0048708	astrocyte differentiation	IDA	J:98270
Biological Process	GO:0048708	astrocyte differentiation	IGI	J:98270
Biological Process	GO:0048708	astrocyte differentiation	IGI	J:98270
Biological Process	GO:0048708	astrocyte differentiation	IDA	J:98270
Biological Process	GO:1905222	atrioventricular canal morphogenesis	IMP	J:110615
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:104417
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:136168
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:110615
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:155856
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:299402
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:299317
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:160796
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:146446
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:101046
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:154664
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:123381
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:217224
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:86665
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	IMP	J:110615
Biological Process	GO:0003130	BMP signaling pathway involved in heart induction	ISO	J:164563
Biological Process	GO:0060348	bone development	IMP	J:163789
Biological Process	GO:0030282	bone mineralization	IGI	J:150546
Biological Process	GO:0030282	bone mineralization	IDA	J:150546
Biological Process	GO:0030282	bone mineralization	IGI	J:150546
Biological Process	GO:0030282	bone mineralization	IDA	J:95992
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IGI	J:99651
Biological Process	GO:0003210	cardiac atrium formation	IMP	J:110615
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1905072	cardiac jelly development	IMP	J:110615
Biological Process	GO:0055007	cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:0055007	cardiac muscle cell differentiation	IGI	J:169047
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	IMP	J:104417
Biological Process	GO:0035051	cardiocyte differentiation	ISO	J:164563
Biological Process	GO:0035051	cardiocyte differentiation	ISO	J:90643
Biological Process	GO:0051216	cartilage development	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0045165	cell fate commitment	IMP	J:80062
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:21055
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:145723
Biological Process	GO:0002062	chondrocyte differentiation	ISO	J:164563
Biological Process	GO:0060128	corticotropin hormone secreting cell differentiation	IDA	J:46975
Biological Process	GO:0009790	embryo development	IMP	J:36213
Biological Process	GO:0035054	embryonic heart tube anterior/posterior pattern specification	IMP	J:104417
Biological Process	GO:0003272	endocardial cushion formation	IMP	J:110615
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:165329
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:104417
Biological Process	GO:0001837	epithelial to mesenchymal transition	IMP	J:110615
Biological Process	GO:0001837	epithelial to mesenchymal transition	IMP	J:178530
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:90643
Biological Process	GO:0010467	gene expression	IDA	J:79855
Biological Process	GO:0007507	heart development	IMP	J:104417
Biological Process	GO:0001701	in utero embryonic development	IMP	J:104417
Biological Process	GO:0006954	inflammatory response	IEP	J:116258
Biological Process	GO:0048839	inner ear development	IDA	J:174607
Biological Process	GO:0048762	mesenchymal cell differentiation	ISO	J:164563
Biological Process	GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	IMP	J:99651
Biological Process	GO:0060485	mesenchyme development	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0032348	negative regulation of aldosterone biosynthetic process	ISO	J:164563
Biological Process	GO:0051042	negative regulation of calcium-independent cell-cell adhesion	ISO	J:164563
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:99651
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:41080
Biological Process	GO:2000065	negative regulation of cortisol biosynthetic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:94493
Biological Process	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	IDA	J:299402
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IGI	J:136168
Biological Process	GO:0010894	negative regulation of steroid biosynthetic process	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:41080
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:47724
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:104417
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IDA	J:94518
Biological Process	GO:0001503	ossification	IEA	J:60000
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:299402
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:163789
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:73065
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:146446
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:150546
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:95960
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:73065
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:102448
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:150546
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:146446
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:146446
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:150546
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:164563
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0060039	pericardium development	IMP	J:104417
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:41080
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IDA	J:57039
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IGI	J:98270
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IDA	J:98270
Biological Process	GO:0030501	positive regulation of bone mineralization	IDA	J:172937
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:1900159	positive regulation of bone mineralization involved in bone maturation	ISO	J:164563
Biological Process	GO:0061036	positive regulation of cartilage development	IDA	J:60610
Biological Process	GO:0061036	positive regulation of cartilage development	ISO	J:15319
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:172937
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	IDA	J:94518
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:104417
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0003331	positive regulation of extracellular matrix constituent secretion	IMP	J:110615
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IDA	J:91833
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:136168
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:110615
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:174146
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	IGI	J:169047
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:33779
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:50621
Biological Process	GO:0042482	positive regulation of odontogenesis	IDA	J:21055
Biological Process	GO:0045778	positive regulation of ossification	ISO	J:41877
Biological Process	GO:0045778	positive regulation of ossification	IDA	J:171138
Biological Process	GO:0045778	positive regulation of ossification	IDA	J:97303
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:172937
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA	J:100164
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA	J:91833
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IMP	J:172937
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010922	positive regulation of phosphatase activity	ISO	J:41877
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:123381
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	IDA	J:136168
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:165329
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:33779
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:33445
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:157651
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:41080
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:50462
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:33445
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:50462
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:3481
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:56303
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	ISO	J:164563
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IDA	J:88480
Biological Process	GO:0060804	positive regulation of Wnt signaling pathway by BMP signaling pathway	IDA	J:150546
Biological Process	GO:0031648	protein destabilization	IGI	J:94493
Biological Process	GO:0031648	protein destabilization	IDA	J:94493
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006029	proteoglycan metabolic process	IGI	J:171806
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0042487	regulation of odontogenesis of dentin-containing tooth	IGI	J:41974
Biological Process	GO:0042487	regulation of odontogenesis of dentin-containing tooth	IGI	J:41974
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0001666	response to hypoxia	IMP	J:157651
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0021537	telencephalon development	ISO	J:41080
Biological Process	GO:0021978	telencephalon regionalization	IGI	J:73082
Biological Process	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	IDA	J:46975
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:56303
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:104417
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TAS	J:36213
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:150546

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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