GO Annotations Graph

• Symbol: Areg
• Name: amphiregulin
• ID: MGI:88068

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:226559
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:193394
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:277693
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:193417
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:34905
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:27180
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:193417
Cellular Component	GO:0005615	extracellular space	IGI	J:277693
Cellular Component	GO:0005615	extracellular space	ISO	J:34905
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:27180
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:27180
Biological Process	GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	IMP	J:120116
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:193394
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:193417
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:277693
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:226559
Biological Process	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	IMP	J:120116
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	ISO	J:34905
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0014009	glial cell proliferation	ISO	J:155856
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:54980
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:54980
Biological Process	GO:0060744	mammary gland branching involved in thelarche	IMP	J:54980
Biological Process	GO:0060744	mammary gland branching involved in thelarche	IMP	J:120116
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:34905
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	IBA	J:265628
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:34905
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0032355	response to estradiol	IDA	J:120116
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:155856