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GO Annotations Graph
Symbol
Name
ID
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
MGI:2659071

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0031697beta-1 adrenergic receptor bindingISOJ:164563
Molecular FunctionGO:0005096GTPase activator activityISOJ:164563
Molecular FunctionGO:0005085guanyl-nucleotide exchange factor activityIEAJ:72247
Molecular FunctionGO:0005085guanyl-nucleotide exchange factor activityIEAJ:60000
Molecular FunctionGO:0030165PDZ domain bindingISOJ:164563
Molecular FunctionGO:0070300phosphatidic acid bindingISOJ:164563
Molecular FunctionGO:0019901protein kinase bindingISOJ:155856
Molecular FunctionGO:0017034Rap guanyl-nucleotide exchange factor activityISOJ:164563
Molecular FunctionGO:0017034Rap guanyl-nucleotide exchange factor activityIDAJ:201420
Molecular FunctionGO:0017034Rap guanyl-nucleotide exchange factor activityIMPJ:152727
Molecular FunctionGO:0017034Rap guanyl-nucleotide exchange factor activityISOJ:155856
Molecular FunctionGO:0005088Ras guanyl-nucleotide exchange factor activityIMPJ:198912
Molecular FunctionGO:0005088Ras guanyl-nucleotide exchange factor activityISOJ:164563
Molecular FunctionGO:0050699WW domain bindingISOJ:164563
Cellular ComponentGO:0016324apical plasma membraneISOJ:164563
Cellular ComponentGO:0005923bicellular tight junctionISOJ:164563
Cellular ComponentGO:0030054cell junctionIEAJ:60000
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005829cytosolISOJ:164563
Cellular ComponentGO:0030139endocytic vesicleISOJ:164563
Cellular ComponentGO:0005768endosomeIEAJ:60000
Cellular ComponentGO:0005770late endosomeISOJ:164563
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0043005neuron projectionISOJ:155856
Cellular ComponentGO:0043025neuronal cell bodyISOJ:155856
Cellular ComponentGO:0048471perinuclear region of cytoplasmISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:155856
Cellular ComponentGO:0043234protein complexISOJ:155856
Cellular ComponentGO:0045202synapseISOJ:155856
Biological ProcessGO:0071880adenylate cyclase-activating adrenergic receptor signaling pathwayISOJ:164563
Biological ProcessGO:0001568blood vessel developmentIMPJ:125199
Biological ProcessGO:0031547brain-derived neurotrophic factor receptor signaling pathwayISOJ:155856
Biological ProcessGO:0019933cAMP-mediated signalingISOJ:164563
Biological ProcessGO:0019933cAMP-mediated signalingIDAJ:201420
Biological ProcessGO:0030154cell differentiationIEAJ:60000
Biological ProcessGO:0071320cellular response to cAMPISOJ:164563
Biological ProcessGO:0071320cellular response to cAMPIMPJ:198912
Biological ProcessGO:0071320cellular response to cAMPIDAJ:201420
Biological ProcessGO:0071321cellular response to cGMPISOJ:164563
Biological ProcessGO:1990090cellular response to nerve growth factor stimulusISOJ:155856
Biological ProcessGO:0061028establishment of endothelial barrierISOJ:164563
Biological ProcessGO:0090557establishment of endothelial intestinal barrierISOJ:164563
Biological ProcessGO:0021884forebrain neuron developmentIMPJ:149445
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayISOJ:164563
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayIDAJ:201420
Biological ProcessGO:0030033microvillus assemblyISOJ:164563
Biological ProcessGO:0007275multicellular organism developmentIEAJ:60000
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationIMPJ:198912
Biological ProcessGO:0050774negative regulation of dendrite morphogenesisISOJ:164563
Biological ProcessGO:0050774negative regulation of dendrite morphogenesisIMPJ:198912
Biological ProcessGO:0048022negative regulation of melanin biosynthetic processIMPJ:198912
Biological ProcessGO:0038180nerve growth factor signaling pathwayISOJ:155856
Biological ProcessGO:0007399nervous system developmentIEAJ:60000
Biological ProcessGO:0001764neuron migrationIMPJ:178740
Biological ProcessGO:0031175neuron projection developmentISOJ:164563
Biological ProcessGO:0031175neuron projection developmentIMPJ:201420
Biological ProcessGO:0007218neuropeptide signaling pathwayISOJ:164563
Biological ProcessGO:0007218neuropeptide signaling pathwayIDAJ:201420
Biological ProcessGO:2000481positive regulation of cAMP-dependent protein kinase activityISOJ:164563
Biological ProcessGO:2000481positive regulation of cAMP-dependent protein kinase activityIMPJ:198912
Biological ProcessGO:0043950positive regulation of cAMP-mediated signalingISOJ:164563
Biological ProcessGO:2000670positive regulation of dendritic cell apoptotic processIMPJ:198912
Biological ProcessGO:2000670positive regulation of dendritic cell apoptotic processISOJ:164563
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:155856
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIMPJ:198912
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIDAJ:201420
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeISOJ:164563
Biological ProcessGO:0043547positive regulation of GTPase activityIDAJ:201420
Biological ProcessGO:0043547positive regulation of GTPase activityIMPJ:198912
Biological ProcessGO:0043547positive regulation of GTPase activityISOJ:155856
Biological ProcessGO:0043547positive regulation of GTPase activityISOJ:164563
Biological ProcessGO:0043547positive regulation of GTPase activityIMPJ:152727
Biological ProcessGO:2001224positive regulation of neuron migrationIMPJ:149445
Biological ProcessGO:0010976positive regulation of neuron projection developmentISOJ:155856
Biological ProcessGO:0032092positive regulation of protein bindingIDAJ:201420
Biological ProcessGO:0045860positive regulation of protein kinase activityISOJ:155856
Biological ProcessGO:0045860positive regulation of protein kinase activityISOJ:164563
Biological ProcessGO:0045860positive regulation of protein kinase activityIDAJ:201420
Biological ProcessGO:2001214positive regulation of vasculogenesisIMPJ:152727
Biological ProcessGO:0072659protein localization to plasma membraneISOJ:164563
Biological ProcessGO:0032486Rap protein signal transductionISOJ:164563
Biological ProcessGO:1901888regulation of cell junction assemblyISOJ:164563
Biological ProcessGO:0042127regulation of cell proliferationIEAJ:72247
Biological ProcessGO:0048167regulation of synaptic plasticityISOJ:155856
Biological ProcessGO:0007165signal transductionIEAJ:72247
Biological ProcessGO:0007264small GTPase mediated signal transductionIEAJ:72247
Biological ProcessGO:0021591ventricular system developmentIMPJ:125199


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory