GO Annotations Graph

• Symbol: Ambra1
• Name: autophagy/beclin 1 regulator 1
• ID: MGI:2443564

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051020	GTPase binding	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:122795
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005930	axoneme	IDA	J:203423
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:314082
Cellular Component	GO:0005737	cytoplasm	ISO	J:122795
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:174518
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:314082
Cellular Component	GO:0005634	nucleus	IDA	J:314089
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:185616
Biological Process	GO:0000045	autophagosome assembly	ISO	J:164563
Biological Process	GO:0006914	autophagy	IBA	J:265628
Biological Process	GO:0006914	autophagy	IMP	J:122795
Biological Process	GO:0000422	autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0009790	embryo development	IMP	J:122795
Biological Process	GO:0000423	mitophagy	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:122795
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:122795
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0021915	neural tube development	IMP	J:122795
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:155856
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:314082
Biological Process	GO:1904544	positive regulation of free ubiquitin chain polymerization	ISO	J:164563
Biological Process	GO:1901526	positive regulation of mitophagy	ISO	J:164563
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:164563
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IMP	J:306277
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:314089
Biological Process	GO:0098780	response to mitochondrial depolarisation	ISO	J:164563