GO Annotations Graph

• Symbol: Plekha1
• Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
• ID: MGI:2442213

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	IBA	J:265628
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0008209	androgen metabolic process	IMP	J:142042
Biological Process	GO:0050853	B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0045184	establishment of protein localization	ISO	J:164563
Biological Process	GO:0008210	estrogen metabolic process	IGI	J:142042
Biological Process	GO:0060325	face morphogenesis	IMP	J:117491
Biological Process	GO:0008585	female gonad development	IGI	J:142042
Biological Process	GO:0033327	Leydig cell differentiation	IMP	J:142042
Biological Process	GO:0001553	luteinization	IGI	J:142042
Biological Process	GO:0035264	multicellular organism growth	IMP	J:117491
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:117491
Biological Process	GO:0009791	post-embryonic development	IMP	J:117491
Biological Process	GO:0060021	roof of mouth development	IMP	J:117491
Biological Process	GO:0031529	ruffle organization	ISO	J:164563
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:117491
Biological Process	GO:0007283	spermatogenesis	IMP	J:142042