GO Annotations Graph

• Symbol: Picalm
• Name: phosphatidylinositol binding clathrin assembly protein
• ID: MGI:2385902

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005545	1-phosphatidylinositol binding	ISO	J:155856
Molecular Function	GO:0005545	1-phosphatidylinositol binding	IBA	J:265628
Molecular Function	GO:0030276	clathrin binding	ISO	J:164563
Molecular Function	GO:0030276	clathrin binding	ISO	J:155856
Molecular Function	GO:0032050	clathrin heavy chain binding	ISO	J:164563
Molecular Function	GO:0032050	clathrin heavy chain binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:155856
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IBA	J:265628
Molecular Function	GO:0005543	phospholipid binding	IEA	J:72247
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	ISO	J:164563
Molecular Function	GO:0000149	SNARE binding	IBA	J:265628
Molecular Function	GO:0048156	tau protein binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0030132	clathrin coat of coated pit	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:84426
Cellular Component	GO:0005905	clathrin-coated pit	IBA	J:265628
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:155856
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0030136	clathrin-coated vesicle	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0070381	endosome to plasma membrane transport vesicle	ISO	J:164563
Cellular Component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	ISO	J:155856
Cellular Component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0097418	neurofibrillary tangle	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:154896
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IBA	J:265628
Cellular Component	GO:0031982	vesicle	IDA	J:186509
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	IMP	J:221101
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	IGI	J:221101
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	ISO	J:164563
Biological Process	GO:0007409	axonogenesis	IMP	J:156045
Biological Process	GO:0007409	axonogenesis	ISO	J:155856
Biological Process	GO:0048268	clathrin coat assembly	ISO	J:164563
Biological Process	GO:0048268	clathrin coat assembly	ISO	J:155856
Biological Process	GO:0048268	clathrin coat assembly	ISO	J:164563
Biological Process	GO:0072583	clathrin-dependent endocytosis	ISO	J:164563
Biological Process	GO:0072583	clathrin-dependent endocytosis	IMP	J:186509
Biological Process	GO:0072583	clathrin-dependent endocytosis	IBA	J:265628
Biological Process	GO:0048813	dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:156045
Biological Process	GO:0006897	endocytosis	ISO	J:164563
Biological Process	GO:0016197	endosomal transport	ISO	J:164563
Biological Process	GO:0030097	hemopoiesis	IMP	J:84426
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0007611	learning or memory	IGI	J:221101
Biological Process	GO:0097753	membrane bending	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP	J:186509
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0048261	negative regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	IMP	J:186509
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	IMP	J:207966
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP	J:186509
Biological Process	GO:0050772	positive regulation of axonogenesis	ISO	J:155856
Biological Process	GO:1903861	positive regulation of dendrite extension	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:2000809	positive regulation of synaptic vesicle clustering	ISO	J:155856
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	IDA	J:84426
Biological Process	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	IEA	J:72247
Biological Process	GO:0030100	regulation of endocytosis	ISO	J:164563
Biological Process	GO:0030100	regulation of endocytosis	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	ISO	J:164563
Biological Process	GO:0051223	regulation of protein transport	ISO	J:155856
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:1902803	regulation of synaptic vesicle transport	ISO	J:155856
Biological Process	GO:2000331	regulation of terminal button organization	ISO	J:155856
Biological Process	GO:0097494	regulation of vesicle size	ISO	J:164563
Biological Process	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane	IBA	J:265628
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0016188	synaptic vesicle maturation	IMP	J:207810
Biological Process	GO:0006900	vesicle budding from membrane	ISO	J:164563
Biological Process	GO:0035459	vesicle cargo loading	IMP	J:186509
Biological Process	GO:0035459	vesicle cargo loading	ISO	J:164563
Biological Process	GO:0016192	vesicle-mediated transport	ISO	J:155856