GO Annotations Graph

• Symbol: Gper1
• Name: G protein-coupled estrogen receptor 1
• ID: MGI:1924104

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:1903924	estradiol binding	ISO	J:155856
Molecular Function	GO:0038054	G protein-coupled estrogen receptor activity	ISO	J:155856
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0030284	nuclear estrogen receptor activity	IDA	J:201283
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:164563
Molecular Function	GO:0030284	nuclear estrogen receptor activity	IBA	J:265628
Molecular Function	GO:0005496	steroid binding	ISO	J:164563
Molecular Function	GO:1990239	steroid hormone binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:200505
Cellular Component	GO:0005737	cytoplasm	IDA	J:201910
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0044327	dendritic spine head	ISO	J:155856
Cellular Component	GO:0032591	dendritic spine membrane	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	EXP	J:263385
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:263385
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0045095	keratin filament	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:201441
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:200505
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:60000
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:200505
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030263	apoptotic chromosome condensation	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:174852
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:200505
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:155856
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:164563
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:201283
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:201910
Biological Process	GO:0071392	cellular response to estradiol stimulus	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	IDA	J:174852
Biological Process	GO:0071389	cellular response to mineralocorticoid stimulus	ISO	J:155856
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	IBA	J:265628
Biological Process	GO:0050804	modulation of chemical synaptic transmission	EXP	J:263385
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:263385
Biological Process	GO:0010948	negative regulation of cell cycle process	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:201910
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0002695	negative regulation of leukocyte activation	ISO	J:164563
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process	IDA	J:201910
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900121	negative regulation of receptor binding	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2000724	positive regulation of cardiac vascular smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA	J:174852
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:155856
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	IDA	J:174852
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:201283
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:174852
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:174852
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:201910
Biological Process	GO:0050769	positive regulation of neurogenesis	IDA	J:201283
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:201283
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:201910
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:174852
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:201283
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	ISO	J:164563
Biological Process	GO:1905152	positive regulation of voltage-gated sodium channel activity	ISO	J:155856
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:201910
Biological Process	GO:0007210	serotonin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0043401	steroid hormone mediated signaling pathway	ISO	J:164563
Biological Process	GO:0042311	vasodilation	ISO	J:155856