GO Annotations Graph

• Symbol: Afg3l2
• Name: AFG3-like AAA ATPase 2
• ID: MGI:1916847

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0004176	ATP-dependent peptidase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:215238
Molecular Function	GO:0005515	protein binding	IPI	J:164484
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005745	m-AAA complex	IBA	J:265628
Cellular Component	GO:0005745	m-AAA complex	IDA	J:164484
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:164484
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IGI	J:156874
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Biological Process	GO:0007409	axonogenesis	ISO	J:164563
Biological Process	GO:0007409	axonogenesis	IMP	J:106411
Biological Process	GO:0036444	calcium import into the mitochondrion	ISO	J:164563
Biological Process	GO:0042407	cristae formation	IGI	J:156874
Biological Process	GO:0042407	cristae formation	IGI	J:156874
Biological Process	GO:0033619	membrane protein proteolysis	ISO	J:164563
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0008053	mitochondrial fusion	IGI	J:156874
Biological Process	GO:0034982	mitochondrial protein processing	IBA	J:265628
Biological Process	GO:0034982	mitochondrial protein processing	IGI	J:156874
Biological Process	GO:0034982	mitochondrial protein processing	IDA	J:164484
Biological Process	GO:0007005	mitochondrion organization	IGI	J:156874
Biological Process	GO:0007005	mitochondrion organization	IGI	J:156874
Biological Process	GO:0055001	muscle cell development	IMP	J:106411
Biological Process	GO:0042552	myelination	IMP	J:106411
Biological Process	GO:0021675	nerve development	IMP	J:106411
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:106411
Biological Process	GO:0016540	protein autoprocessing	IMP	J:164484
Biological Process	GO:0016485	protein processing	IDA	J:164484
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:106411
Biological Process	GO:0060013	righting reflex	IMP	J:106411