GO Annotations Graph

• Symbol: Zmpste24
• Name: zinc metallopeptidase, STE24
• ID: MGI:1890508

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003690	double-stranded DNA binding	IGI	J:216917
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:123768
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IMP	J:79501
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:235285
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0004222	metalloendopeptidase activity	IMP	J:70661
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:70661
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:72247
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0016020	membrane	IDA	J:70661
Cellular Component	GO:0005635	nuclear envelope	IDA	J:99634
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:241516
Biological Process	GO:0007628	adult walking behavior	IMP	J:76209
Biological Process	GO:0030282	bone mineralization	IGI	J:199185
Biological Process	GO:0071586	CAAX-box protein processing	IBA	J:265628
Biological Process	GO:1990036	calcium ion import into sarcoplasmic reticulum	IMP	J:238852
Biological Process	GO:0061762	CAMKK-AMPK signaling cascade	IMP	J:136907
Biological Process	GO:0061337	cardiac conduction	IMP	J:238852
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:76209
Biological Process	GO:0003231	cardiac ventricle development	IMP	J:76209
Biological Process	GO:0044255	cellular lipid metabolic process	IMP	J:76209
Biological Process	GO:0071480	cellular response to gamma radiation	IMP	J:99634
Biological Process	GO:0006325	chromatin organization	IMP	J:134546
Biological Process	GO:0006325	chromatin organization	IMP	J:216121
Biological Process	GO:0051276	chromosome organization	IMP	J:99634
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:134546
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:136907
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:244335
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:76209
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:174530
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:174530
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:238852
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:99634
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:199185
Biological Process	GO:0006974	DNA damage response	IMP	J:134546
Biological Process	GO:0006974	DNA damage response	IMP	J:173189
Biological Process	GO:0006974	DNA damage response	IMP	J:99634
Biological Process	GO:0006281	DNA repair	IMP	J:99634
Biological Process	GO:0006281	DNA repair	IGI	J:174530
Biological Process	GO:0006281	DNA repair	IMP	J:174530
Biological Process	GO:0008544	epidermis development	IMP	J:76209
Biological Process	GO:0003417	growth plate cartilage development	IMP	J:76209
Biological Process	GO:0001942	hair follicle development	IMP	J:76209
Biological Process	GO:0003007	heart morphogenesis	IMP	J:76209
Biological Process	GO:0006925	inflammatory cell apoptotic process	IMP	J:76209
Biological Process	GO:0060993	kidney morphogenesis	IMP	J:76209
Biological Process	GO:0001889	liver development	IMP	J:216917
Biological Process	GO:0043007	maintenance of rDNA	IMP	J:216121
Biological Process	GO:0035264	multicellular organism growth	IGI	J:199185
Biological Process	GO:0035264	multicellular organism growth	IMP	J:76209
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:216917
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:134546
Biological Process	GO:1903799	negative regulation of miRNA processing	IMP	J:173189
Biological Process	GO:1903799	negative regulation of miRNA processing	IGI	J:173189
Biological Process	GO:0050905	neuromuscular process	IGI	J:199185
Biological Process	GO:0050905	neuromuscular process	IMP	J:76209
Biological Process	GO:0006998	nuclear envelope organization	IMP	J:79501
Biological Process	GO:0006998	nuclear envelope organization	IDA	J:235285
Biological Process	GO:0006998	nuclear envelope organization	IDA	J:123768
Biological Process	GO:0006998	nuclear envelope organization	IGI	J:95274
Biological Process	GO:0006998	nuclear envelope organization	IMP	J:76209
Biological Process	GO:0006998	nuclear envelope organization	IMP	J:95274
Biological Process	GO:0006998	nuclear envelope organization	IMP	J:216121
Biological Process	GO:0006997	nucleus organization	IGI	J:106473
Biological Process	GO:0006997	nucleus organization	IMP	J:76209
Biological Process	GO:0006997	nucleus organization	IMP	J:134546
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:238972
Biological Process	GO:0044029	positive regulation of gene expression via CpG island demethylation	IMP	J:216121
Biological Process	GO:0030327	prenylated protein catabolic process	IDA	J:70661
Biological Process	GO:0051604	protein maturation	IDA	J:123768
Biological Process	GO:0051604	protein maturation	IMP	J:79501
Biological Process	GO:0051604	protein maturation	IDA	J:235285
Biological Process	GO:0016485	protein processing	IMP	J:76209
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0010506	regulation of autophagy	IMP	J:136907
Biological Process	GO:1903522	regulation of blood circulation	IMP	J:136907
Biological Process	GO:0030500	regulation of bone mineralization	IGI	J:244335
Biological Process	GO:0008360	regulation of cell shape	IMP	J:134546
Biological Process	GO:2000772	regulation of cellular senescence	IMP	J:174530
Biological Process	GO:2000772	regulation of cellular senescence	IMP	J:134546
Biological Process	GO:2000772	regulation of cellular senescence	IGI	J:199185
Biological Process	GO:0050688	regulation of defense response to virus	IMP	J:241516
Biological Process	GO:0050688	regulation of defense response to virus	ISO	J:241516
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	IMP	J:134546
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	IGI	J:173189
Biological Process	GO:0044030	regulation of DNA methylation	IMP	J:216121
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:216121
Biological Process	GO:0048145	regulation of fibroblast proliferation	IMP	J:134546
Biological Process	GO:0010906	regulation of glucose metabolic process	IMP	J:136907
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:238852
Biological Process	GO:0032350	regulation of hormone metabolic process	IMP	J:136907
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:136907
Biological Process	GO:0007346	regulation of mitotic cell cycle	IMP	J:134546
Biological Process	GO:1903463	regulation of mitotic cell cycle DNA replication	IMP	J:99634
Biological Process	GO:0040014	regulation of multicellular organism growth	IGI	J:244335
Biological Process	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IMP	J:99634
Biological Process	GO:0070302	regulation of stress-activated protein kinase signaling cascade	IMP	J:134546
Biological Process	GO:2000730	regulation of termination of RNA polymerase I transcription	IMP	J:216121
Biological Process	GO:0032006	regulation of TOR signaling	IMP	J:136907
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IMP	J:238852
Biological Process	GO:0072423	response to DNA damage checkpoint signaling	IMP	J:99634
Biological Process	GO:0048538	thymus development	IMP	J:76209
Biological Process	GO:0003229	ventricular cardiac muscle tissue development	IMP	J:238852