GO Annotations Graph

• Symbol: Irf3
• Name: interferon regulatory factor 3
• ID: MGI:1859179

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IMP	J:235021
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:236952
Molecular Function	GO:0042802	identical protein binding	IPI	J:154027
Molecular Function	GO:0042802	identical protein binding	IPI	J:153697
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:86256
Molecular Function	GO:0042802	identical protein binding	ISO	J:280922
Molecular Function	GO:0042802	identical protein binding	IPI	J:84679
Molecular Function	GO:0042802	identical protein binding	IPI	J:84679
Molecular Function	GO:0042802	identical protein binding	IPI	J:84896
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:141299
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0140537	transcription regulator activator activity	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1810458
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:173334
Cellular Component	GO:0005634	nucleus	IDA	J:96405
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:173334
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IDA	J:141299
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:235021
Biological Process	GO:0051607	defense response to virus	IMP	J:153410
Biological Process	GO:0051607	defense response to virus	IMP	J:167950
Biological Process	GO:0051607	defense response to virus	IMP	J:199310
Biological Process	GO:0002376	immune system process	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84679
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0009299	mRNA transcription	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:235021
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:153410
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:153410
Biological Process	GO:0032728	positive regulation of interferon-beta production	TAS	J:184127
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:280922
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	IMP	J:123411
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:199310
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0050727	regulation of inflammatory response	IGI	J:239522
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0009617	response to bacterium	IDA	J:96405
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84896
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84896
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032606	type I interferon production	IGI	J:97662
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IMP	J:235021