GO Annotations Graph

• Symbol: Kdm2a
• Name: lysine (K)-specific demethylase 2A
• ID: MGI:1354736

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0032452	histone demethylase activity	IBA	J:265628
Molecular Function	GO:0051864	histone H3K36 demethylase activity	ISO	J:73065
Molecular Function	GO:0140680	histone H3K36me/H3K36me2 demethylase activity	IEA	J:72245
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0045322	unmethylated CpG binding	ISO	J:164563
Molecular Function	GO:0045322	unmethylated CpG binding	IDA	J:162939
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:322373
Cellular Component	GO:0000785	chromatin	IDA	J:162939
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0032922	circadian regulation of gene expression	ISO	J:164563
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0001947	heart looping	IMP	J:217589
Biological Process	GO:0070544	histone H3-K36 demethylation	IMP	J:322373
Biological Process	GO:0001701	in utero embryonic development	IMP	J:217589
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IMP	J:217589
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:217589
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:217589
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:217589
Biological Process	GO:0060563	neuroepithelial cell differentiation	IMP	J:217589
Biological Process	GO:0030182	neuron differentiation	IMP	J:217589
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:217589
Biological Process	GO:0006482	protein demethylation	IBA	J:265628
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000