GO Annotations Graph

• Symbol: Esr1
• Name: estrogen receptor 1 (alpha)
• ID: MGI:1352467

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:122948
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:207622
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003682	chromatin binding	IDA	J:134051
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0034056	estrogen response element binding	ISO	J:164563
Molecular Function	GO:0034056	estrogen response element binding	IBA	J:265628
Molecular Function	GO:0038054	G protein-coupled estrogen receptor activity	ISO	J:164563
Molecular Function	GO:0042562	hormone binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:164563
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:155856
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:94471
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:73065
Molecular Function	GO:0003707	nuclear steroid receptor activity	ISO	J:155856
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:217463
Molecular Function	GO:0005515	protein binding	IPI	J:238452
Molecular Function	GO:0005515	protein binding	IPI	J:37212
Molecular Function	GO:0005515	protein binding	IPI	J:182421
Molecular Function	GO:0005515	protein binding	IPI	J:239215
Molecular Function	GO:0005515	protein binding	IPI	J:113940
Molecular Function	GO:0005515	protein binding	IPI	J:103776
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0005515	protein binding	IPI	J:125396
Molecular Function	GO:0005515	protein binding	IPI	J:99324
Molecular Function	GO:0005515	protein binding	IPI	J:134051
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:239215
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0005496	steroid binding	ISO	J:155856
Molecular Function	GO:0017025	TBP-class protein binding	ISO	J:164563
Molecular Function	GO:0001093	TFIIB-class transcription factor binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:157316
Molecular Function	GO:0008134	transcription factor binding	IPI	J:157008
Molecular Function	GO:0031798	type 1 metabotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:85930
Cellular Component	GO:0005737	cytoplasm	IDA	J:105918
Cellular Component	GO:0000791	euchromatin	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:105918
Cellular Component	GO:0005634	nucleus	IDA	J:134051
Cellular Component	GO:0005634	nucleus	IDA	J:117151
Cellular Component	GO:0005634	nucleus	IDA	J:38668
Cellular Component	GO:0005634	nucleus	IDA	J:89713
Cellular Component	GO:0005634	nucleus	IDA	J:75909
Cellular Component	GO:0005634	nucleus	IDA	J:85930
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Biological Process	GO:0008209	androgen metabolic process	IMP	J:147000
Biological Process	GO:0001547	antral ovarian follicle growth	IMP	J:64426
Biological Process	GO:0071392	cellular response to estradiol stimulus	IDA	J:239215
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:155856
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:164563
Biological Process	GO:0071391	cellular response to estrogen stimulus	IBA	J:265628
Biological Process	GO:0071391	cellular response to estrogen stimulus	IMP	J:130045
Biological Process	GO:0002064	epithelial cell development	IMP	J:147000
Biological Process	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	IMP	J:109714
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:147000
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:147000
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008584	male gonad development	IMP	J:147000
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:64639
Biological Process	GO:0060745	mammary gland branching involved in pregnancy	IMP	J:64639
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0046325	negative regulation of glucose import	ISO	J:155856
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1902894	negative regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0045839	negative regulation of mitotic nuclear division	NAS	J:115547
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0090209	negative regulation of triglyceride metabolic process	ISO	J:155856
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:147000
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0010863	positive regulation of phospholipase C activity	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:130045
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:71406
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP	J:145499
Biological Process	GO:0060523	prostate epithelial cord elongation	IMP	J:145499
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	IMP	J:96107
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	IMP	J:147000
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:94471
Biological Process	GO:1904035	regulation of epithelial cell apoptotic process	IMP	J:130045
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:184829
Biological Process	GO:0043523	regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0034121	regulation of toll-like receptor signaling pathway	IMP	J:184829
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032355	response to estradiol	ISO	J:164563
Biological Process	GO:0043627	response to estrogen	ISO	J:164563
Biological Process	GO:0051123	RNA polymerase II preinitiation complex assembly	ISO	J:164563
Biological Process	GO:0060011	Sertoli cell proliferation	ISO	J:155856
Biological Process	GO:0048863	stem cell differentiation	IDA	J:220326
Biological Process	GO:0043401	steroid hormone mediated signaling pathway	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:130045
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:130045
Biological Process	GO:0060065	uterus development	IGI	J:64426
Biological Process	GO:0060068	vagina development	IGI	J:64426