GO Annotations Graph

• Symbol: Spo11
• Name: SPO11 initiator of meiotic double stranded breaks
• ID: MGI:1349669

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA	J:72247
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA	J:72245
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:229524
Cellular Component	GO:0005694	chromosome	IEA	J:72247
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:158887
Cellular Component	GO:0000228	nuclear chromosome	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912344
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912357
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0006259	DNA metabolic process	IEA	J:72247
Biological Process	GO:1990918	double-strand break repair involved in meiotic recombination	IGI	J:236226
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IMP	J:140402
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IMP	J:209347
Biological Process	GO:0000237	leptotene	IMP	J:147391
Biological Process	GO:0007141	male meiosis I	IMP	J:140402
Biological Process	GO:0007141	male meiosis I	IMP	J:123677
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0042138	meiotic DNA double-strand break formation	IBA	J:265628
Biological Process	GO:0000706	meiotic DNA double-strand break processing	IBA	J:265628
Biological Process	GO:0045141	meiotic telomere clustering	IMP	J:147391
Biological Process	GO:0048477	oogenesis	IMP	J:213984
Biological Process	GO:0001541	ovarian follicle development	IMP	J:96250
Biological Process	GO:0034502	protein localization to chromosome	IMP	J:161203
Biological Process	GO:0007131	reciprocal meiotic recombination	IBA	J:265628
Biological Process	GO:0007131	reciprocal meiotic recombination	IMP	J:104590
Biological Process	GO:0007286	spermatid development	IMP	J:123677
Biological Process	GO:0007130	synaptonemal complex assembly	IGI	J:209347
Biological Process	GO:0007130	synaptonemal complex assembly	IMP	J:236226
Biological Process	GO:0007130	synaptonemal complex assembly	IGI	J:209347