GO Annotations Graph

• Symbol: Ddr2
• Name: discoidin domain receptor family, member 2
• ID: MGI:1345277

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005518	collagen binding	ISO	J:155856
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	IBA	J:265628
Molecular Function	GO:0005518	collagen binding	IDA	J:111768
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0038062	protein tyrosine kinase collagen receptor activity	ISO	J:164563
Molecular Function	GO:0038062	protein tyrosine kinase collagen receptor activity	IDA	J:74327
Molecular Function	GO:0038062	protein tyrosine kinase collagen receptor activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0031214	biomineral tissue development	IMP	J:183213
Biological Process	GO:0035988	chondrocyte proliferation	IMP	J:74580
Biological Process	GO:0030199	collagen fibril organization	IMP	J:183213
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	ISO	J:164563
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	IDA	J:74327
Biological Process	GO:0003416	endochondral bone growth	IMP	J:74580
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	ISO	J:155856
Biological Process	GO:0033673	negative regulation of kinase activity	ISO	J:155856
Biological Process	GO:0060547	negative regulation of necrotic cell death	ISO	J:155856
Biological Process	GO:0001503	ossification	IEA	J:60000
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:74327
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	IMP	J:74327
Biological Process	GO:0010763	positive regulation of fibroblast migration	IMP	J:74327
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:74327
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:74580
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:155856
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:1904899	positive regulation of hepatic stellate cell proliferation	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	IBA	J:265628
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:111768
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0030500	regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0034103	regulation of tissue remodeling	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:74327