GO Annotations Graph

• Symbol: Ppargc1a
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
• ID: MGI:1342774

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:130306
Molecular Function	GO:0003677	DNA binding	IDA	J:96189
Molecular Function	GO:0106222	lncRNA binding	IPI	J:239614
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0030374	nuclear receptor coactivator activity	ISO	J:164563
Molecular Function	GO:0030374	nuclear receptor coactivator activity	IBA	J:265628
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:114687
Molecular Function	GO:0005515	protein binding	IPI	J:128527
Molecular Function	GO:0005515	protein binding	IPI	J:214637
Molecular Function	GO:0005515	protein binding	IPI	J:96630
Molecular Function	GO:0005515	protein binding	IPI	J:129744
Molecular Function	GO:0005515	protein binding	IPI	J:129891
Molecular Function	GO:0005515	protein binding	IPI	J:122764
Molecular Function	GO:0005515	protein binding	IPI	J:98701
Molecular Function	GO:0005515	protein binding	IPI	J:87780
Molecular Function	GO:0005515	protein binding	IPI	J:153416
Molecular Function	GO:0005515	protein binding	IPI	J:162572
Molecular Function	GO:0005515	protein binding	IPI	J:88279
Molecular Function	GO:0005515	protein binding	IPI	J:88279
Molecular Function	GO:0005515	protein binding	IPI	J:88279
Molecular Function	GO:0005515	protein binding	IPI	J:129766
Molecular Function	GO:0003723	RNA binding	IEA	J:72247
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:147973
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IEA	J:72247
Molecular Function	GO:0003713	transcription coactivator activity	IMP	J:114735
Molecular Function	GO:0003713	transcription coactivator activity	IDA	J:122764
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:155856
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:249196
Molecular Function	GO:0003712	transcription coregulator activity	IDA	J:147973
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Molecular Function	GO:0140537	transcription regulator activator activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:249196
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0022626	cytosolic ribosome	ISO	J:155856
Cellular Component	GO:0000791	euchromatin	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1368101
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1605464
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1605475
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-3903005
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-556760
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663294
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623231
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623232
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623284
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9717150
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:130306
Biological Process	GO:0060612	adipose tissue development	IMP	J:181203
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	ISO	J:155856
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:162076
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0032922	circadian regulation of gene expression	IDA	J:122764
Biological Process	GO:0097009	energy homeostasis	IMP	J:192024
Biological Process	GO:0097009	energy homeostasis	IMP	J:147973
Biological Process	GO:0006094	gluconeogenesis	ISO	J:164563
Biological Process	GO:0006094	gluconeogenesis	IDA	J:98701
Biological Process	GO:0007005	mitochondrion organization	ISO	J:155856
Biological Process	GO:0007005	mitochondrion organization	IMP	J:239614
Biological Process	GO:0007005	mitochondrion organization	IDA	J:239614
Biological Process	GO:0045820	negative regulation of glycolytic process	ISO	J:155856
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:162076
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:2000272	negative regulation of signaling receptor activity	ISO	J:155856
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:162076
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	IMP	J:192024
Biological Process	GO:1901857	positive regulation of cellular respiration	IMP	J:192024
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:93896
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:156035
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:219185
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:96189
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:88279
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1901860	positive regulation of mitochondrial DNA metabolic process	IMP	J:192024
Biological Process	GO:0010822	positive regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0010822	positive regulation of mitochondrion organization	IMP	J:192024
Biological Process	GO:1901863	positive regulation of muscle tissue development	IMP	J:192024
Biological Process	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	IMP	J:147973
Biological Process	GO:1904635	positive regulation of podocyte apoptotic process	ISO	J:155856
Biological Process	GO:2000184	positive regulation of progesterone biosynthetic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:167144
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:92557
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162572
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:92557
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0042752	regulation of circadian rhythm	IDA	J:122764
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:249196
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0022904	respiratory electron transport chain	IDA	J:88279
Biological Process	GO:0014823	response to activity	ISO	J:155856
Biological Process	GO:1903494	response to dehydroepiandrosterone	ISO	J:155856
Biological Process	GO:0002021	response to dietary excess	IDA	J:210952
Biological Process	GO:1990910	response to hypobaric hypoxia	ISO	J:155856
Biological Process	GO:0014850	response to muscle activity	IMP	J:167144
Biological Process	GO:0014850	response to muscle activity	IDA	J:170051
Biological Process	GO:0048511	rhythmic process	IEA	J:60000