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GO Annotations Graph
Symbol
Name
ID
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0071074eukaryotic initiation factor eIF2 bindingICJ:124910
Molecular FunctionGO:0004694eukaryotic translation initiation factor 2alpha kinase activityIMPJ:124910
Molecular FunctionGO:0004694eukaryotic translation initiation factor 2alpha kinase activityISOJ:164563
Molecular FunctionGO:0004694eukaryotic translation initiation factor 2alpha kinase activityIDAJ:51759
Molecular FunctionGO:0004694eukaryotic translation initiation factor 2alpha kinase activityISOJ:155856
Molecular FunctionGO:0051879Hsp90 protein bindingISOJ:155856
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:85958
Molecular FunctionGO:0005515protein bindingIPIJ:201928
Molecular FunctionGO:0005515protein bindingIPIJ:201928
Molecular FunctionGO:0005515protein bindingIPIJ:201568
Molecular FunctionGO:0005515protein bindingIPIJ:200066
Molecular FunctionGO:0005515protein bindingIPIJ:149195
Molecular FunctionGO:0004672protein kinase activityIMPJ:94221
Molecular FunctionGO:0004672protein kinase activityIDAJ:85958
Molecular FunctionGO:0004672protein kinase activityIDAJ:85958
Molecular FunctionGO:0019903protein phosphatase bindingISOJ:164563
Molecular FunctionGO:0004674protein serine/threonine kinase activityISOJ:155856
Molecular FunctionGO:0004674protein serine/threonine kinase activityIDAJ:51759
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Cellular ComponentGO:0005737cytoplasmIDAJ:73377
Cellular ComponentGO:0005783endoplasmic reticulumIDAJ:85958
Cellular ComponentGO:0005783endoplasmic reticulumIDAJ:70005
Cellular ComponentGO:0005789endoplasmic reticulum membraneIDAJ:51759
Cellular ComponentGO:0016021integral component of membraneIEAJ:60000
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0048471perinuclear region of cytoplasmISOJ:155856
Biological ProcessGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIMPJ:62257
Biological ProcessGO:0001525angiogenesisISOJ:164563
Biological ProcessGO:0030282bone mineralizationIMPJ:76661
Biological ProcessGO:0019722calcium-mediated signalingIMPJ:105342
Biological ProcessGO:0034198cellular response to amino acid starvationISOJ:164563
Biological ProcessGO:0070417cellular response to coldISOJ:164563
Biological ProcessGO:0042149cellular response to glucose starvationISOJ:164563
Biological ProcessGO:0042149cellular response to glucose starvationIMPJ:215862
Biological ProcessGO:0002063chondrocyte developmentIMPJ:84818
Biological ProcessGO:0036492eiF2alpha phosphorylation in response to endoplasmic reticulum stressISOJ:164563
Biological ProcessGO:0031018endocrine pancreas developmentISOJ:164563
Biological ProcessGO:0007029endoplasmic reticulum organizationIMPJ:70005
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseISOJ:164563
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIMPJ:107108
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIMPJ:62257
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIMPJ:99655
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIMPJ:94221
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIMPJ:70005
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIDAJ:85958
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseIDAJ:51759
Biological ProcessGO:0006983ER overload responseISOJ:164563
Biological ProcessGO:0045444fat cell differentiationIDAJ:141100
Biological ProcessGO:0048009insulin-like growth factor receptor signaling pathwayIMPJ:84818
Biological ProcessGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMPJ:70005
Biological ProcessGO:0007595lactationIMPJ:141100
Biological ProcessGO:0043066negative regulation of apoptotic processIMPJ:94221
Biological ProcessGO:0010629negative regulation of gene expressionIMPJ:195351
Biological ProcessGO:0031642negative regulation of myelinationIMPJ:99655
Biological ProcessGO:0017148negative regulation of translationIDAJ:51759
Biological ProcessGO:0017148negative regulation of translationIMPJ:201568
Biological ProcessGO:0017148negative regulation of translationIMPJ:62257
Biological ProcessGO:0017148negative regulation of translationIMPJ:107108
Biological ProcessGO:0017148negative regulation of translationIGIJ:107108
Biological ProcessGO:1902010negative regulation of translation in response to endoplasmic reticulum stressIDAJ:51759
Biological ProcessGO:0032055negative regulation of translation in response to stressISOJ:155856
Biological ProcessGO:0001503ossificationISOJ:164563
Biological ProcessGO:0031016pancreas developmentIMPJ:76661
Biological ProcessGO:0018105peptidyl-serine phosphorylationIDAJ:51759
Biological ProcessGO:0018105peptidyl-serine phosphorylationIDAJ:217285
Biological ProcessGO:0036499PERK-mediated unfolded protein responseIMPJ:124910
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayIGIJ:203180
Biological ProcessGO:0010628positive regulation of gene expressionISOJ:164563
Biological ProcessGO:0010628positive regulation of gene expressionIMPJ:124910
Biological ProcessGO:1903788positive regulation of glutathione biosynthetic processIMPJ:218003
Biological ProcessGO:0032092positive regulation of protein bindingIMPJ:105342
Biological ProcessGO:1900182positive regulation of protein localization to nucleusIMPJ:85958
Biological ProcessGO:1900182positive regulation of protein localization to nucleusIMPJ:218003
Biological ProcessGO:0009967positive regulation of signal transductionIDAJ:141100
Biological ProcessGO:0045943positive regulation of transcription from RNA polymerase I promoterISOJ:164563
Biological ProcessGO:0045943positive regulation of transcription from RNA polymerase I promoterIMPJ:215862
Biological ProcessGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressIMPJ:124910
Biological ProcessGO:0010575positive regulation of vascular endothelial growth factor productionIMPJ:215862
Biological ProcessGO:0010575positive regulation of vascular endothelial growth factor productionISOJ:164563
Biological ProcessGO:0046777protein autophosphorylationISOJ:164563
Biological ProcessGO:0046777protein autophosphorylationIMPJ:94221
Biological ProcessGO:0046777protein autophosphorylationISOJ:155856
Biological ProcessGO:0046777protein autophosphorylationIDAJ:51759
Biological ProcessGO:0046777protein autophosphorylationIDAJ:201568
Biological ProcessGO:0051260protein homooligomerizationISOJ:164563
Biological ProcessGO:0006468protein phosphorylationIMPJ:76661
Biological ProcessGO:0006468protein phosphorylationIDAJ:82058
Biological ProcessGO:0006468protein phosphorylationIMPJ:94221
Biological ProcessGO:0006468protein phosphorylationIMPJ:62257
Biological ProcessGO:0006468protein phosphorylationIDAJ:85958
Biological ProcessGO:0006468protein phosphorylationIDAJ:51759
Biological ProcessGO:0006468protein phosphorylationISOJ:155856
Biological ProcessGO:0006468protein phosphorylationIMPJ:107108
Biological ProcessGO:0006468protein phosphorylationIMPJ:70005
Biological ProcessGO:0006468protein phosphorylationIDAJ:85958
Biological ProcessGO:0006468protein phosphorylationIMPJ:62257
Biological ProcessGO:0060734regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylationIMPJ:99455
Biological ProcessGO:1902235regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayISOJ:164563
Biological ProcessGO:0019217regulation of fatty acid metabolic processIMPJ:141100
Biological ProcessGO:0006417regulation of translationIEAJ:60000
Biological ProcessGO:0010998regulation of translational initiation by eIF2 alpha phosphorylationIDAJ:217285
Biological ProcessGO:0010998regulation of translational initiation by eIF2 alpha phosphorylationIMPJ:62257
Biological ProcessGO:0010998regulation of translational initiation by eIF2 alpha phosphorylationIMPJ:99455
Biological ProcessGO:0010998regulation of translational initiation by eIF2 alpha phosphorylationIMPJ:124910
Biological ProcessGO:0034976response to endoplasmic reticulum stressISOJ:164563
Biological ProcessGO:0034976response to endoplasmic reticulum stressIDAJ:99455
Biological ProcessGO:0034976response to endoplasmic reticulum stressIMPJ:218003
Biological ProcessGO:0006986response to unfolded proteinIEAJ:60000
Biological ProcessGO:0001501skeletal system developmentIMPJ:76661
Biological ProcessGO:0032933SREBP signaling pathwayIDAJ:141100
Biological ProcessGO:0006412translationIDAJ:82058


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/02/2021
MGI 6.16
The Jackson Laboratory