GO Annotations Graph

• Symbol: Cldn5
• Name: claudin 5
• ID: MGI:1276112

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:58914
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Cellular Component	GO:0016327	apicolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	IBA	J:265628
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:200284
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:181271
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:181271
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:280103
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0033270	paranode region of axon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:235423
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	ISO	J:155856
Cellular Component	GO:0070160	tight junction	IDA	J:280385
Cellular Component	GO:0070160	tight junction	ISO	J:164563
Biological Process	GO:0070830	bicellular tight junction assembly	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	IC	J:94757
Biological Process	GO:0007043	cell-cell junction assembly	ISO	J:164563
Biological Process	GO:1990963	establishment of blood-retinal barrier	ISO	J:164563
Biological Process	GO:0035633	maintenance of blood-brain barrier	ISO	J:164563
Biological Process	GO:0042552	myelination	ISO	J:155856
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:280385
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:164563
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:280385
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0120192	tight junction assembly	IMP	J:280385
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563