GO Annotations Graph

• Symbol: Tert
• Name: telomerase reverse transcriptase
• ID: MGI:1202709

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:150343
Molecular Function	GO:0005515	protein binding	IPI	J:217943
Molecular Function	GO:0005515	protein binding	IPI	J:217943
Molecular Function	GO:0005515	protein binding	IPI	J:217943
Molecular Function	GO:0005515	protein binding	IPI	J:118302
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IPI	J:227389
Molecular Function	GO:0003968	RNA-dependent RNA polymerase activity	ISO	J:164563
Molecular Function	GO:0003964	RNA-directed DNA polymerase activity	ISO	J:164563
Molecular Function	GO:0003720	telomerase activity	ISO	J:164563
Molecular Function	GO:0003720	telomerase activity	TAS	J:100644
Molecular Function	GO:0003720	telomerase activity	IDA	J:87581
Molecular Function	GO:0070034	telomerase RNA binding	ISO	J:164563
Molecular Function	GO:0070034	telomerase RNA binding	IPI	J:227389
Molecular Function	GO:0070034	telomerase RNA binding	IBA	J:265628
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	ISO	J:164563
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	IBA	J:265628
Molecular Function	GO:0042162	telomeric DNA binding	IBA	J:265628
Molecular Function	GO:0098680	template-free RNA nucleotidyltransferase	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	IPI	J:150343
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0000049	tRNA binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:217943
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0042645	mitochondrial nucleoid	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:215869
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:217943
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0031379	RNA-directed RNA polymerase complex	ISO	J:164563
Cellular Component	GO:0000333	telomerase catalytic core complex	IMP	J:100470
Cellular Component	GO:0000333	telomerase catalytic core complex	ISO	J:164563
Cellular Component	GO:0000333	telomerase catalytic core complex	IBA	J:265628
Cellular Component	GO:0005697	telomerase holoenzyme complex	NAS	J:320115
Cellular Component	GO:0005697	telomerase holoenzyme complex	ISO	J:164563
Cellular Component	GO:1990572	TERT-RMRP complex	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0071897	DNA biosynthetic process	ISO	J:164563
Biological Process	GO:0022616	DNA strand elongation	ISO	J:164563
Biological Process	GO:0070200	establishment of protein localization to telomere	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:155856
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0060253	negative regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	IMP	J:217943
Biological Process	GO:0042635	positive regulation of hair cycle	IMP	J:100644
Biological Process	GO:0042635	positive regulation of hair cycle	IMP	J:100470
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:1904751	positive regulation of protein localization to nucleolus	ISO	J:164563
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:100470
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:100644
Biological Process	GO:1903620	positive regulation of transdifferentiation	ISO	J:155856
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IGI	J:150343
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0090399	replicative senescence	ISO	J:164563
Biological Process	GO:0006278	RNA-templated DNA biosynthetic process	ISO	J:164563
Biological Process	GO:0001172	RNA-templated transcription	ISO	J:164563
Biological Process	GO:0030422	siRNA processing	ISO	J:164563
Biological Process	GO:0140745	siRNA transcription	ISO	J:164563
Biological Process	GO:0007004	telomere maintenance via telomerase	NAS	J:320115
Biological Process	GO:0007004	telomere maintenance via telomerase	TAS	J:100644
Biological Process	GO:0007004	telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0007004	telomere maintenance via telomerase	IBA	J:265628