Smad7 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smad7
SMAD family member 7
MGI:1100518

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200447
Molecular Function	GO:0005515	protein binding	IPI	J:180466
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Molecular Function	GO:0140416	transcription regulator inhibitor activity	IBA	J:265628
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2167872
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2167888
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2167890
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2169016
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2169036
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2169043
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176393
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176396
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176427
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176428
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176431
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2179307
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2179313
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2167888
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2169004
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2169012
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2169016
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2176428
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2176430
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2186775
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:109361
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:198828
Cellular Component	GO:0032991	protein-containing complex	IDA	J:109361
Cellular Component	GO:0005667	transcription regulator complex	IEA	J:72247
Biological Process	GO:0034333	adherens junction assembly	ISO	J:164563
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0048844	artery morphogenesis	IMP	J:145777
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IMP	J:204644
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:157031
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	IDA	J:281197
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	IDA	J:281197
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	IMP	J:204644
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	IMP	J:204644
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0002725	negative regulation of T cell cytokine production	IMP	J:220376
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IMP	J:220376
Biological Process	GO:2000317	negative regulation of T-helper 17 type immune response	IMP	J:220376
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	IMP	J:145777
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	IMP	J:204644
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:1903043	positive regulation of chondrocyte hypertrophy	IDA	J:281197
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0031503	protein-containing complex localization	ISO	J:164563
Biological Process	GO:0032925	regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IMP	J:145777
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IC	J:145777
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IC	J:145777
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:72786
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP	J:145777
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:145777

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23