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GO Annotations Graph
Symbol
Name
ID
Smad7
SMAD family member 7
MGI:1100518

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0048185activin bindingISOJ:164563
Molecular FunctionGO:0008013beta-catenin bindingISOJ:164563
Molecular FunctionGO:0005518collagen bindingIPIJ:86396
Molecular FunctionGO:0003677DNA bindingIEAJ:60000
Molecular FunctionGO:0070411I-SMAD bindingISOJ:164563
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:180466
Molecular FunctionGO:0005515protein bindingIPIJ:109361
Molecular FunctionGO:0005515protein bindingIPIJ:109361
Molecular FunctionGO:0005515protein bindingIPIJ:200447
Molecular FunctionGO:0005515protein bindingIPIJ:109361
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIEAJ:72247
Molecular FunctionGO:0044212transcription regulatory region DNA bindingISOJ:164563
Molecular FunctionGO:0030617transforming growth factor beta receptor, inhibitory cytoplasmic mediator activityISOJ:164563
Molecular FunctionGO:0034713type I transforming growth factor beta receptor bindingISOJ:164563
Molecular FunctionGO:0031625ubiquitin protein ligase bindingISOJ:164563
Molecular FunctionGO:0031625ubiquitin protein ligase bindingISOJ:155856
Cellular ComponentGO:0016342colocalizes_with
catenin complex
ISOJ:164563
Cellular ComponentGO:0005913colocalizes_with
cell-cell adherens junction
ISOJ:164563
Cellular ComponentGO:0005813centrosomeISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005622intracellularIEAJ:72247
Cellular ComponentGO:0005730nucleolusISOJ:164563
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:154112
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:109361
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0043234protein complexISOJ:198828
Cellular ComponentGO:0043234protein complexIDAJ:109361
Cellular ComponentGO:0005667transcription factor complexIEAJ:72247
Biological ProcessGO:0034333adherens junction assemblyISOJ:164563
Biological ProcessGO:0048844artery morphogenesisIMPJ:145777
Biological ProcessGO:0034629cellular protein complex localizationISOJ:164563
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusISOJ:164563
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusIMPJ:204644
Biological ProcessGO:0035556intracellular signal transductionISOJ:155856
Biological ProcessGO:0030514negative regulation of BMP signaling pathwayIDAJ:157031
Biological ProcessGO:0030514negative regulation of BMP signaling pathwayISOJ:164563
Biological ProcessGO:0060394negative regulation of pathway-restricted SMAD protein phosphorylationISOJ:164563
Biological ProcessGO:0033137negative regulation of peptidyl-serine phosphorylationIMPJ:204644
Biological ProcessGO:0033137negative regulation of peptidyl-serine phosphorylationISOJ:164563
Biological ProcessGO:0010801negative regulation of peptidyl-threonine phosphorylationIMPJ:204644
Biological ProcessGO:0010801negative regulation of peptidyl-threonine phosphorylationISOJ:164563
Biological ProcessGO:0031397negative regulation of protein ubiquitinationISOJ:164563
Biological ProcessGO:0043433negative regulation of sequence-specific DNA binding transcription factor activityISOJ:164563
Biological ProcessGO:0010944negative regulation of transcription by competitive promoter bindingISOJ:164563
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayISOJ:164563
Biological ProcessGO:0051444negative regulation of ubiquitin-protein transferase activityISOJ:164563
Biological ProcessGO:0060389pathway-restricted SMAD protein phosphorylationIMPJ:145777
Biological ProcessGO:0022409positive regulation of cell-cell adhesionIMPJ:204644
Biological ProcessGO:0022409positive regulation of cell-cell adhesionISOJ:164563
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processISOJ:164563
Biological ProcessGO:0031398positive regulation of protein ubiquitinationISOJ:164563
Biological ProcessGO:0050821protein stabilizationISOJ:164563
Biological ProcessGO:0032925regulation of activin receptor signaling pathwayISOJ:164563
Biological ProcessGO:0055117regulation of cardiac muscle contractionIMPJ:145777
Biological ProcessGO:0010717regulation of epithelial to mesenchymal transitionISOJ:164563
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:72247
Biological ProcessGO:0006355regulation of transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0017015regulation of transforming growth factor beta receptor signaling pathwayICJ:145777
Biological ProcessGO:0017015regulation of transforming growth factor beta receptor signaling pathwayISOJ:155856
Biological ProcessGO:0060373regulation of ventricular cardiac muscle cell membrane depolarizationICJ:145777
Biological ProcessGO:0006351transcription, DNA-templatedIEAJ:60000
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayIDAJ:72786
Biological ProcessGO:0055010ventricular cardiac muscle tissue morphogenesisIMPJ:145777
Biological ProcessGO:0060412ventricular septum morphogenesisIMPJ:145777


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory