GO Annotations Graph

• Symbol: Tnfsf11
• Name: tumor necrosis factor (ligand) superfamily, member 11
• ID: MGI:1100089

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:74774
Molecular Function	GO:0005515	protein binding	IPI	J:235251
Molecular Function	GO:0005515	protein binding	IPI	J:245306
Molecular Function	GO:0005515	protein binding	IPI	J:245342
Molecular Function	GO:0005515	protein binding	IPI	J:74774
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	IEA	J:72247
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	IPI	J:44239
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:52369
Biological Process	GO:0060348	bone development	IMP	J:223062
Biological Process	GO:0045453	bone resorption	IDA	J:81173
Biological Process	GO:0055074	calcium ion homeostasis	IGI	J:177648
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:235251
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:146763
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:149238
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0007254	JNK cascade	IGI	J:180994
Biological Process	GO:0048535	lymph node development	TAS	J:60454
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:64718
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:64718
Biological Process	GO:0002548	monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:322376
Biological Process	GO:0001503	ossification	IMP	J:52369
Biological Process	GO:0036035	osteoclast development	IDA	J:178250
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:164563
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:97515
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:95156
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:95156
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:86931
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:114609
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:97566
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:145836
Biological Process	GO:0002158	osteoclast proliferation	IDA	J:193006
Biological Process	GO:0038001	paracrine signaling	IDA	J:211901
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:164563
Biological Process	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	IDA	J:155398
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:155398
Biological Process	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	ISO	J:164563
Biological Process	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	IDA	J:155398
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:145836
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:153524
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:149238
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IGI	J:180994
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:2001206	positive regulation of osteoclast development	IDA	J:202853
Biological Process	GO:2001206	positive regulation of osteoclast development	IDA	J:134223
Biological Process	GO:2001206	positive regulation of osteoclast development	IDA	J:196719
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IGI	J:166692
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IDA	J:97566
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IDA	J:95992
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IGI	J:177648
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IGI	J:114609
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IGI	J:177648
Biological Process	GO:0042327	positive regulation of phosphorylation	IDA	J:146763
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:64718
Biological Process	GO:0050870	positive regulation of T cell activation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:64718
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:64718
Biological Process	GO:1904616	regulation of actin binding	IDA	J:153524
Biological Process	GO:0045670	regulation of osteoclast differentiation	IDA	J:81173
Biological Process	GO:0045670	regulation of osteoclast differentiation	IDA	J:198051
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	IDA	J:134223
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	IDA	J:196719
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	IDA	J:145836
Biological Process	GO:0044691	tooth eruption	IMP	J:223062
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IGI	J:155398