Nrxn1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nrxn1
neurexin I
MGI:1096391

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0033130	acetylcholine receptor binding	IDA	J:153439
Molecular Function	GO:0005246	calcium channel regulator activity	IGI	J:89452
Molecular Function	GO:0005246	calcium channel regulator activity	IGI	J:89452
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0048306	calcium-dependent protein binding	IDA	J:175147
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:175310
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:175147
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:84070
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:175310
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0097109	neuroligin family protein binding	IPI	J:175310
Molecular Function	GO:0097109	neuroligin family protein binding	ISO	J:155856
Molecular Function	GO:0097109	neuroligin family protein binding	IPI	J:84070
Molecular Function	GO:0097109	neuroligin family protein binding	IPI	J:175147
Molecular Function	GO:0005515	protein binding	IPI	J:269669
Molecular Function	GO:0005515	protein binding	IPI	J:165995
Molecular Function	GO:0005515	protein binding	IPI	J:200384
Molecular Function	GO:0005515	protein binding	IPI	J:171950
Molecular Function	GO:0005515	protein binding	IPI	J:256117
Molecular Function	GO:0005515	protein binding	IPI	J:201987
Molecular Function	GO:0005515	protein binding	IPI	J:171950
Molecular Function	GO:0005515	protein binding	IPI	J:171950
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:84070
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:155856
Molecular Function	GO:0005105	type 1 fibroblast growth factor receptor binding	ISO	J:164563
Cellular Component	GO:0044295	axonal growth cone	IDA	J:84070
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:175147
Cellular Component	GO:0009986	cell surface	IDA	J:175310
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:142497
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:142497
Cellular Component	GO:0060076	excitatory synapse	NAS	J:138036
Cellular Component	GO:0098982	GABA-ergic synapse	NAS	J:319984
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:175189
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:175189
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:175189
Cellular Component	GO:0098978	glutamatergic synapse	NAS	J:319984
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:177327
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263410
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:175189
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:175189
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:175189
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:292715
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:142497
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:142497
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:142497
Cellular Component	GO:0060077	inhibitory synapse	IC	J:84070
Cellular Component	GO:0060077	inhibitory synapse	NAS	J:138036
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031594	neuromuscular junction	NAS	J:320287
Cellular Component	GO:0098984	neuron to neuron synapse	NAS	J:319989
Cellular Component	GO:0043025	neuronal cell body	IDA	J:142497
Cellular Component	GO:0043025	neuronal cell body	IDA	J:142497
Cellular Component	GO:0031965	nuclear membrane	IDA	J:142497
Cellular Component	GO:0031965	nuclear membrane	IDA	J:142497
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IC	J:175310
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:263410
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:263410
Cellular Component	GO:0048787	presynaptic active zone membrane	IMP	J:263410
Cellular Component	GO:0048787	presynaptic active zone membrane	IMP	J:263410
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:89452
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:142497
Cellular Component	GO:0042734	presynaptic membrane	IMP	J:142497
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:142497
Cellular Component	GO:0042734	presynaptic membrane	IMP	J:142497
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:142497
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:142497
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:263444
Cellular Component	GO:0042734	presynaptic membrane	IMP	J:263444
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:263444
Cellular Component	GO:0098635	protein complex involved in cell-cell adhesion	ISO	J:164563
Cellular Component	GO:0098635	protein complex involved in cell-cell adhesion	EXP	J:245291
Cellular Component	GO:0032991	protein-containing complex	IPI	J:211830
Cellular Component	GO:0032991	protein-containing complex	IPI	J:211830
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:142497
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:142497
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:142497
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:153748
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:153748
Cellular Component	GO:0036057	slit diaphragm	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0031982	vesicle	IDA	J:142497
Cellular Component	GO:0031982	vesicle	IDA	J:142497
Biological Process	GO:0030534	adult behavior	IMP	J:153748
Biological Process	GO:0030534	adult behavior	ISO	J:164563
Biological Process	GO:0030534	adult behavior	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	J:84070
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	J:245291
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0090125	cell-cell adhesion involved in synapse maturation	NAS	J:319989
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:155856
Biological Process	GO:0021707	cerebellar granule cell differentiation	IGI	J:165995
Biological Process	GO:0007268	chemical synaptic transmission	IGI	J:89452
Biological Process	GO:0007268	chemical synaptic transmission	IGI	J:89452
Biological Process	GO:0045184	establishment of protein localization	IDA	J:84070
Biological Process	GO:0046847	filopodium assembly	IMP	J:180545
Biological Process	GO:0097112	gamma-aminobutyric acid receptor clustering	IDA	J:175189
Biological Process	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	IDA	J:175189
Biological Process	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	IDA	J:175310
Biological Process	GO:0097117	guanylate kinase-associated protein clustering	IDA	J:175189
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	J:84070
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IGI	J:165995
Biological Process	GO:0007612	learning	ISO	J:164563
Biological Process	GO:0007612	learning	IMP	J:153748
Biological Process	GO:0007612	learning	ISO	J:164563
Biological Process	GO:0099558	maintenance of synapse structure	NAS	J:319951
Biological Process	GO:0051490	negative regulation of filopodium assembly	IDA	J:180545
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	IDA	J:175310
Biological Process	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	IDA	J:175189
Biological Process	GO:0050885	neuromuscular process controlling balance	IMP	J:153748
Biological Process	GO:0007158	neuron cell-cell adhesion	IDA	J:84070
Biological Process	GO:0007158	neuron cell-cell adhesion	NAS	J:319989
Biological Process	GO:0042551	neuron maturation	IDA	J:175189
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0048812	neuron projection morphogenesis	NAS	J:319951
Biological Process	GO:0007269	neurotransmitter secretion	TAS	J:45298
Biological Process	GO:0007269	neurotransmitter secretion	IGI	J:89452
Biological Process	GO:0007269	neurotransmitter secretion	IGI	J:89452
Biological Process	GO:0097114	NMDA glutamate receptor clustering	IDA	J:175189
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:153748
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IDA	J:175147
Biological Process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1900075	positive regulation of neuromuscular synaptic transmission	NAS	J:320287
Biological Process	GO:0010976	positive regulation of neuron projection development	NAS	J:319951
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900020	positive regulation of protein kinase C activity	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	IDA	J:175147
Biological Process	GO:0051965	positive regulation of synapse assembly	IGI	J:171950
Biological Process	GO:0051965	positive regulation of synapse assembly	IGI	J:171950
Biological Process	GO:0090129	positive regulation of synapse maturation	IDA	J:153439
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	NAS	J:319984
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP	J:153748
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	NAS	J:319984
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IDA	J:175147
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	IDA	J:175310
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	IDA	J:175189
Biological Process	GO:0097104	postsynaptic membrane assembly	IDA	J:175189
Biological Process	GO:0097104	postsynaptic membrane assembly	IDA	J:175310
Biological Process	GO:0060134	prepulse inhibition	IMP	J:153748
Biological Process	GO:0099054	presynapse assembly	ISO	J:155856
Biological Process	GO:0099054	presynapse assembly	IMP	J:177327
Biological Process	GO:0099054	presynapse assembly	IDA	J:177327
Biological Process	GO:0099054	presynapse assembly	IDA	J:177327
Biological Process	GO:0099054	presynapse assembly	IPI	J:177327
Biological Process	GO:0097105	presynaptic membrane assembly	IDA	J:84070
Biological Process	GO:0035418	protein localization to synapse	IDA	J:84070
Biological Process	GO:0090126	protein-containing complex assembly involved in synapse maturation	IDA	J:84070
Biological Process	GO:0097120	receptor localization to synapse	IDA	J:175189
Biological Process	GO:2000311	regulation of AMPA receptor activity	IDA	J:175147
Biological Process	GO:2000311	regulation of AMPA receptor activity	IDA	J:180545
Biological Process	GO:2000821	regulation of grooming behavior	IMP	J:153748
Biological Process	GO:2000310	regulation of NMDA receptor activity	IDA	J:175147
Biological Process	GO:0099151	regulation of postsynaptic density assembly	IDA	J:177327
Biological Process	GO:0099151	regulation of postsynaptic density assembly	IDA	J:177327
Biological Process	GO:0099151	regulation of postsynaptic density assembly	IMP	J:177327
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly	IDA	J:175189
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly	IDA	J:175189
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly	IMP	J:175189
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly	IDA	J:175189
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly	IMP	J:175189
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly	IDA	J:175189
Biological Process	GO:1905606	regulation of presynapse assembly	IMP	J:263410
Biological Process	GO:1905606	regulation of presynapse assembly	IDA	J:263410
Biological Process	GO:1905606	regulation of presynapse assembly	IDA	J:263410
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IDA	J:153748
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	IMP	J:153748
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA	J:224592
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP	J:224592
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP	J:224592
Biological Process	GO:0150036	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA	J:224592
Biological Process	GO:0007165	signal transduction	IDA	J:84070
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0035176	social behavior	ISO	J:164563
Biological Process	GO:0035176	social behavior	ISO	J:164563
Biological Process	GO:0007416	synapse assembly	NAS	J:319989
Biological Process	GO:0007416	synapse assembly	IGI	J:89452
Biological Process	GO:0007416	synapse assembly	IGI	J:89452
Biological Process	GO:0007416	synapse assembly	IGI	J:171950
Biological Process	GO:0007416	synapse assembly	IGI	J:171950
Biological Process	GO:0007416	synapse assembly	IGI	J:171950
Biological Process	GO:0007416	synapse assembly	IGI	J:171950
Biological Process	GO:0007416	synapse assembly	IMP	J:292715
Biological Process	GO:0007416	synapse assembly	IMP	J:292715
Biological Process	GO:0007416	synapse assembly	IPI	J:292715
Biological Process	GO:0007416	synapse assembly	IDA	J:292715
Biological Process	GO:0007416	synapse assembly	IDA	J:292715
Biological Process	GO:0007416	synapse assembly	IMP	J:292715
Biological Process	GO:0007416	synapse assembly	IPI	J:292715
Biological Process	GO:0007416	synapse assembly	IDA	J:292715
Biological Process	GO:0060074	synapse maturation	NAS	J:319989
Biological Process	GO:0099560	synaptic membrane adhesion	IMP	J:230665
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:84070
Biological Process	GO:0099560	synaptic membrane adhesion	IMP	J:84070
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:84070
Biological Process	GO:0097091	synaptic vesicle clustering	IDA	J:84070
Biological Process	GO:0042297	vocal learning	ISO	J:164563
Biological Process	GO:0071625	vocalization behavior	ISO	J:164563
Biological Process	GO:0071625	vocalization behavior	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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