GO Annotations Graph

• Symbol: Gckr
• Name: glucokinase regulatory protein
• ID: MGI:1096345

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030246	carbohydrate binding	ISO	J:155856
Molecular Function	GO:0030246	carbohydrate binding	IBA	J:265628
Molecular Function	GO:0097367	carbohydrate derivative binding	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	IBA	J:265628
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:155856
Molecular Function	GO:0004857	enzyme inhibitor activity	IBA	J:265628
Molecular Function	GO:0070095	fructose-6-phosphate binding	ISO	J:164563
Molecular Function	GO:0070095	fructose-6-phosphate binding	IBA	J:265628
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:61183
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:58949
Biological Process	GO:1901135	carbohydrate derivative metabolic process	IEA	J:72247
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0042593	glucose homeostasis	IBA	J:265628
Biological Process	GO:0001678	intracellular glucose homeostasis	IMP	J:58949
Biological Process	GO:0033132	negative regulation of glucokinase activity	ISO	J:155856
Biological Process	GO:0033132	negative regulation of glucokinase activity	ISO	J:164563
Biological Process	GO:0033132	negative regulation of glucokinase activity	IBA	J:265628
Biological Process	GO:0033132	negative regulation of glucokinase activity	IMP	J:61183
Biological Process	GO:1903300	negative regulation of hexokinase activity	ISO	J:155856
Biological Process	GO:0033133	positive regulation of glucokinase activity	IMP	J:61183
Biological Process	GO:0006606	protein import into nucleus	ISO	J:155856
Biological Process	GO:0006606	protein import into nucleus	IMP	J:58949
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:61183
Biological Process	GO:0009750	response to fructose	ISO	J:164563
Biological Process	GO:0009750	response to fructose	ISO	J:155856
Biological Process	GO:0009750	response to fructose	IBA	J:265628
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:164563
Biological Process	GO:0046415	urate metabolic process	ISO	J:164563