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GO Annotations Graph
Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0010997anaphase-promoting complex bindingISOJ:164563
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0042802identical protein bindingISOJ:164563
Molecular FunctionGO:0051717inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activityISOJ:164563
Molecular FunctionGO:0000287magnesium ion bindingIEAJ:72247
Molecular FunctionGO:0030165PDZ domain bindingISOJ:164563
Molecular FunctionGO:0030165PDZ domain bindingISOJ:155856
Molecular FunctionGO:0016791phosphatase activityIEAJ:72247
Molecular FunctionGO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activityISOJ:155856
Molecular FunctionGO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activityIDAJ:77008
Molecular FunctionGO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activityISOJ:164563
Molecular FunctionGO:0051800phosphatidylinositol-3,4-bisphosphate 3-phosphatase activityISOJ:164563
Molecular FunctionGO:0004438phosphatidylinositol-3-phosphatase activityISOJ:164563
Molecular FunctionGO:0004721phosphoprotein phosphatase activityISOJ:164563
Molecular FunctionGO:0005161platelet-derived growth factor receptor bindingISOJ:155856
Molecular FunctionGO:0005515protein bindingIPIJ:136033
Molecular FunctionGO:0005515protein bindingIPIJ:105981
Molecular FunctionGO:0005515protein bindingIPIJ:120364
Molecular FunctionGO:0005515protein bindingIPIJ:169887
Molecular FunctionGO:0005515protein bindingIPIJ:105981
Molecular FunctionGO:0005515protein bindingIPIJ:191729
Molecular FunctionGO:0005515protein bindingIPIJ:160700
Molecular FunctionGO:0019901protein kinase bindingIPIJ:178436
Molecular FunctionGO:0004722protein serine/threonine phosphatase activityISOJ:164563
Molecular FunctionGO:0004725protein tyrosine phosphatase activityISOJ:164563
Molecular FunctionGO:0008138protein tyrosine/serine/threonine phosphatase activityIEAJ:72247
Cellular ComponentGO:0016324apical plasma membraneISOJ:164563
Cellular ComponentGO:0042995cell projectionISOJ:164563
Cellular ComponentGO:0005737cytoplasmIDAJ:137202
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmIDAJ:93902
Cellular ComponentGO:0009898cytoplasmic side of plasma membraneISOJ:164563
Cellular ComponentGO:0043197dendritic spineISOJ:155856
Cellular ComponentGO:0005739mitochondrionISOJ:155856
Cellular ComponentGO:0035749myelin sheath adaxonal regionIDAJ:159103
Cellular ComponentGO:0043005neuron projectionISOJ:155856
Cellular ComponentGO:0043005neuron projectionIDAJ:175650
Cellular ComponentGO:0043005neuron projectionIMPJ:175650
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:136033
Cellular ComponentGO:0005634nucleusIDAJ:137202
Cellular ComponentGO:0005634nucleusIDAJ:93902
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0005634nucleusISOJ:164563
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0045211postsynaptic membraneISOJ:155856
Cellular ComponentGO:0043220Schmidt-Lanterman incisureIDAJ:159103
Biological ProcessGO:0007092activation of APC-Cdc20 complex activityISOJ:164563
Biological ProcessGO:0007092activation of APC-Cdc20 complex activityIMPJ:173135
Biological ProcessGO:0030534adult behaviorIMPJ:109635
Biological ProcessGO:0001525angiogenesisIMPJ:100493
Biological ProcessGO:0006915apoptotic processIEAJ:60000
Biological ProcessGO:0048854brain morphogenesisIMPJ:144937
Biological ProcessGO:0060070canonical Wnt signaling pathwayISOJ:164563
Biological ProcessGO:0048738cardiac muscle tissue developmentIMPJ:100493
Biological ProcessGO:0016477cell migrationIMPJ:77123
Biological ProcessGO:0036294cellular response to decreased oxygen levelsIDAJ:213269
Biological ProcessGO:0071456cellular response to hypoxiaIDAJ:213269
Biological ProcessGO:0007417central nervous system developmentIMPJ:77123
Biological ProcessGO:0032286central nervous system myelin maintenanceIMPJ:130843
Biological ProcessGO:0021955central nervous system neuron axonogenesisIMPJ:109635
Biological ProcessGO:0060997dendritic spine morphogenesisIMPJ:130843
Biological ProcessGO:0060997dendritic spine morphogenesisIMPJ:184118
Biological ProcessGO:0021542dentate gyrus developmentIMPJ:125726
Biological ProcessGO:0016311dephosphorylationIEAJ:72247
Biological ProcessGO:0043542endothelial cell migrationIMPJ:100493
Biological ProcessGO:0048853forebrain morphogenesisIMPJ:109635
Biological ProcessGO:0007507heart developmentIMPJ:98216
Biological ProcessGO:0046855inositol phosphate dephosphorylationISOJ:164563
Biological ProcessGO:0007611learning or memoryIMPJ:109635
Biological ProcessGO:0006629lipid metabolic processIEAJ:60000
Biological ProcessGO:0045475locomotor rhythmIMPJ:125726
Biological ProcessGO:0007626locomotory behaviorIMPJ:109635
Biological ProcessGO:0060292long term synaptic depressionISOJ:155856
Biological ProcessGO:0060291long-term synaptic potentiationIMPJ:130843
Biological ProcessGO:0060179male mating behaviorIMPJ:109635
Biological ProcessGO:0042711maternal behaviorIMPJ:109635
Biological ProcessGO:0007613memoryISOJ:155856
Biological ProcessGO:0033555multicellular organismal response to stressIMPJ:109635
Biological ProcessGO:0043066negative regulation of apoptotic processIMPJ:71874
Biological ProcessGO:0050771negative regulation of axonogenesisIMPJ:109635
Biological ProcessGO:0090344negative regulation of cell agingIMPJ:173135
Biological ProcessGO:0030336negative regulation of cell migrationISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:164563
Biological ProcessGO:0008285negative regulation of cell proliferationIMPJ:100095
Biological ProcessGO:0008285negative regulation of cell proliferationIGIJ:100094
Biological ProcessGO:0008285negative regulation of cell proliferationISOJ:155856
Biological ProcessGO:0045792negative regulation of cell sizeIMPJ:109635
Biological ProcessGO:0045792negative regulation of cell sizeIMPJ:184118
Biological ProcessGO:0031658negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleISOJ:164563
Biological ProcessGO:0061002negative regulation of dendritic spine morphogenesisIMPJ:109635
Biological ProcessGO:0050680negative regulation of epithelial cell proliferationIMPJ:99524
Biological ProcessGO:0090394negative regulation of excitatory postsynaptic potentialIMPJ:184118
Biological ProcessGO:0051895negative regulation of focal adhesion assemblyISOJ:164563
Biological ProcessGO:2000134negative regulation of G1/S transition of mitotic cell cycleISOJ:164563
Biological ProcessGO:0031642negative regulation of myelinationIMPJ:160700
Biological ProcessGO:0046621negative regulation of organ growthIMPJ:144937
Biological ProcessGO:0050765negative regulation of phagocytosisISOJ:155856
Biological ProcessGO:0051898negative regulation of protein kinase B signalingIMPJ:160700
Biological ProcessGO:0051898negative regulation of protein kinase B signalingIMPJ:216935
Biological ProcessGO:0051898negative regulation of protein kinase B signalingIMPJ:109635
Biological ProcessGO:0051898negative regulation of protein kinase B signalingIMPJ:71874
Biological ProcessGO:0051898negative regulation of protein kinase B signalingISOJ:164563
Biological ProcessGO:0001933negative regulation of protein phosphorylationIMPJ:225488
Biological ProcessGO:0001933negative regulation of protein phosphorylationISOJ:164563
Biological ProcessGO:0090071negative regulation of ribosome biogenesisIMPJ:130843
Biological ProcessGO:2000808negative regulation of synaptic vesicle clusteringIMPJ:109635
Biological ProcessGO:2000808negative regulation of synaptic vesicle clusteringIMPJ:130843
Biological ProcessGO:0007399nervous system developmentIEAJ:60000
Biological ProcessGO:0031175neuron projection developmentISOJ:155856
Biological ProcessGO:0007270neuron-neuron synaptic transmissionIMPJ:130843
Biological ProcessGO:0035335peptidyl-tyrosine dephosphorylationISOJ:164563
Biological ProcessGO:0046856phosphatidylinositol dephosphorylationISOJ:164563
Biological ProcessGO:0046856phosphatidylinositol dephosphorylationISOJ:155856
Biological ProcessGO:0048008platelet-derived growth factor receptor signaling pathwayISOJ:155856
Biological ProcessGO:0043065positive regulation of apoptotic processISOJ:155856
Biological ProcessGO:2001235positive regulation of apoptotic signaling pathwayIMPJ:77008
Biological ProcessGO:0008284positive regulation of cell proliferationIMPJ:173135
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIMPJ:216935
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialIMPJ:130843
Biological ProcessGO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processISOJ:164563
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISOJ:164563
Biological ProcessGO:0097107postsynaptic density assemblyIMPJ:130843
Biological ProcessGO:0060134prepulse inhibitionIMPJ:109635
Biological ProcessGO:0060134prepulse inhibitionIMPJ:144937
Biological ProcessGO:0097105presynaptic membrane assemblyIMPJ:130843
Biological ProcessGO:0060736prostate gland growthIMPJ:99524
Biological ProcessGO:0006470protein dephosphorylationISOJ:164563
Biological ProcessGO:0043491protein kinase B signalingIMPJ:178436
Biological ProcessGO:0043491protein kinase B signalingIMPJ:225488
Biological ProcessGO:0050821protein stabilizationISOJ:164563
Biological ProcessGO:0048679regulation of axon regenerationIGIJ:213126
Biological ProcessGO:0002902regulation of B cell apoptotic processIMPJ:53065
Biological ProcessGO:0051726regulation of cell cycleIGIJ:136033
Biological ProcessGO:0032535regulation of cellular component sizeIMPJ:130843
Biological ProcessGO:0060341regulation of cellular localizationIMPJ:170129
Biological ProcessGO:0033032regulation of myeloid cell apoptotic processIMPJ:53065
Biological ProcessGO:0010975regulation of neuron projection developmentIMPJ:154919
Biological ProcessGO:0031647regulation of protein stabilityISOJ:164563
Biological ProcessGO:0032228regulation of synaptic transmission, GABAergicIMPJ:213269
Biological ProcessGO:0060024rhythmic synaptic transmissionIMPJ:125726
Biological ProcessGO:0035176social behaviorIMPJ:144937
Biological ProcessGO:0035176social behaviorIMPJ:109635
Biological ProcessGO:0007416synapse assemblyIMPJ:109635
Biological ProcessGO:0060074synapse maturationIMPJ:130843


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory