GO Annotations Graph

• Symbol: Htr2a
• Name: 5-hydroxytryptamine (serotonin) receptor 2A
• ID: MGI:109521

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	ISO	J:164563
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:31112
Molecular Function	GO:0001587	Gq/11-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051378	serotonin binding	ISO	J:164563
Molecular Function	GO:0051378	serotonin binding	ISO	J:31112
Cellular Component	GO:0070852	cell body fiber	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0007202	activation of phospholipase C activity	ISO	J:164563
Biological Process	GO:0014824	artery smooth muscle contraction	ISO	J:155856
Biological Process	GO:0007610	behavior	IEA	J:60000
Biological Process	GO:0048148	behavioral response to cocaine	ISO	J:155856
Biological Process	GO:0008219	cell death	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	ISO	J:31112
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006096	glycolytic process	IMP	J:128329
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:128392
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:128392
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:182833
Biological Process	GO:0045821	positive regulation of glycolytic process	IMP	J:128329
Biological Process	GO:0033674	positive regulation of kinase activity	IMP	J:128392
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:128392
Biological Process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0044380	protein localization to cytoskeleton	IDA	J:128392
Biological Process	GO:0014059	regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0030431	sleep	ISO	J:155856
Biological Process	GO:0001659	temperature homeostasis	ISO	J:155856
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	ISO	J:155856