Sema4d GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
MGI:109244

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:22692
Molecular Function	GO:0030215	semaphorin receptor binding	IPI	J:178104
Molecular Function	GO:0030215	semaphorin receptor binding	ISO	J:164563
Molecular Function	GO:0030215	semaphorin receptor binding	IBA	J:265628
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:96745
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:96745
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:178104
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	TAS	J:178104
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IDA	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IDA	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0007409	axonogenesis	IGI	J:96745
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0070486	leukocyte aggregation	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	IBA	J:265628
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	IDA	J:178104
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	ISO	J:164563
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	IBA	J:265628
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IBA	J:265628
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:178104
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IDA	J:178104
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:178104
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001755	neural crest cell migration	IBA	J:265628
Biological Process	GO:0043931	ossification involved in bone maturation	IMP	J:178104
Biological Process	GO:0043931	ossification involved in bone maturation	ISO	J:164563
Biological Process	GO:0043931	ossification involved in bone maturation	IBA	J:265628
Biological Process	GO:0050772	positive regulation of axonogenesis	IDA	J:96745
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:96745
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:96745
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:96745
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:96745
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IDA	J:178104
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0048672	positive regulation of collateral sprouting	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IMP	J:178104
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:1905704	positive regulation of inhibitory synapse assembly	IDA	J:198674
Biological Process	GO:1905704	positive regulation of inhibitory synapse assembly	IMP	J:268255
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:178104
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031344	regulation of cell projection organization	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0048814	regulation of dendrite morphogenesis	ISO	J:164563
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	ISO	J:164563
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IBA	J:265628
Biological Process	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	IMP	J:178104

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23