GO Annotations Graph

• Symbol: Slc12a3
• Name: solute carrier family 12, member 3
• ID: MGI:108114

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015377	chloride:monoatomic cation symporter activity	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:224865
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	IDA	J:148080
Molecular Function	GO:0015378	sodium:chloride symporter activity	IDA	J:331463
Molecular Function	GO:0015378	sodium:chloride symporter activity	ISO	J:155856
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	IBA	J:265628
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Molecular Function	GO:0022857	transmembrane transporter activity	IEA	J:72247
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:121606
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:284463
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:103213
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:171500
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:171500
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:73065
Cellular Component	GO:0005829	cytosol	IDA	J:148080
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:148080
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0006884	cell volume homeostasis	IBA	J:265628
Biological Process	GO:0071241	cellular response to inorganic substance	IDA	J:187157
Biological Process	GO:0055064	chloride ion homeostasis	IBA	J:265628
Biological Process	GO:1902476	chloride transmembrane transport	IBA	J:265628
Biological Process	GO:0006821	chloride transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0055075	potassium ion homeostasis	IBA	J:265628
Biological Process	GO:1990573	potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:187157
Biological Process	GO:1904044	response to aldosterone	IDA	J:152706
Biological Process	GO:0002021	response to dietary excess	IDA	J:187157
Biological Process	GO:0007165	signal transduction	IMP	J:187157
Biological Process	GO:0055078	sodium ion homeostasis	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	IDA	J:202993
Biological Process	GO:0006814	sodium ion transport	IMP	J:148080
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247