Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables sodium:chloride symporter activity. Involved in several processes, including response to aldosterone; response to dietary excess; and sodium ion transmembrane transport. Located in apical plasma membrane and cytosol. Is expressed in metanephros. Used to study Gitelman syndrome. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3).