GO Annotations Graph

• Symbol: Ezh2
• Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
• ID: MGI:107940

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0003682	chromatin binding	IDA	J:218234
Molecular Function	GO:0003682	chromatin binding	IDA	J:202816
Molecular Function	GO:0003682	chromatin binding	IDA	J:93445
Molecular Function	GO:0003682	chromatin binding	IDA	J:180185
Molecular Function	GO:0003682	chromatin binding	IDA	J:189224
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:211907
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:134766
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:211907
Molecular Function	GO:0003677	DNA binding	IDA	J:202488
Molecular Function	GO:0046976	histone H3K27 methyltransferase activity	IMP	J:116444
Molecular Function	GO:0046976	histone H3K27 methyltransferase activity	ISO	J:164563
Molecular Function	GO:0046976	histone H3K27 methyltransferase activity	IBA	J:265628
Molecular Function	GO:0140951	histone H3K27 trimethyltransferase activity	IEA	J:72245
Molecular Function	GO:0042054	histone methyltransferase activity	IDA	J:84664
Molecular Function	GO:0042054	histone methyltransferase activity	ISO	J:73065
Molecular Function	GO:0106222	lncRNA binding	IDA	J:240516
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0070878	primary miRNA binding	IDA	J:211907
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:247419
Molecular Function	GO:0005515	protein binding	IPI	J:178953
Molecular Function	GO:0005515	protein binding	IPI	J:116444
Molecular Function	GO:0005515	protein binding	IPI	J:200345
Molecular Function	GO:0005515	protein binding	IPI	J:198819
Molecular Function	GO:0005515	protein binding	IPI	J:198821
Molecular Function	GO:0005515	protein binding	IPI	J:198819
Molecular Function	GO:0005515	protein binding	IPI	J:158991
Molecular Function	GO:0005515	protein binding	IPI	J:206847
Molecular Function	GO:0005515	protein binding	IPI	J:175603
Molecular Function	GO:0005515	protein binding	IPI	J:157630
Molecular Function	GO:0005515	protein binding	IPI	J:157724
Molecular Function	GO:0005515	protein binding	IPI	J:157724
Molecular Function	GO:0005515	protein binding	IPI	J:84664
Molecular Function	GO:0005515	protein binding	IPI	J:84664
Molecular Function	GO:0005515	protein binding	IPI	J:47703
Molecular Function	GO:0005515	protein binding	IPI	J:119650
Molecular Function	GO:0005515	protein binding	IPI	J:166345
Molecular Function	GO:0005515	protein binding	IPI	J:204177
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	ISO	J:148615
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	IDA	J:218234
Molecular Function	GO:0043021	ribonucleoprotein complex binding	IDA	J:168094
Molecular Function	GO:0003723	RNA binding	IPI	J:225861
Molecular Function	GO:0003723	RNA binding	IDA	J:177132
Molecular Function	GO:0003723	RNA binding	IPI	J:167127
Molecular Function	GO:0003723	RNA binding	IPI	J:188128
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:211907
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA	J:164377
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IMP	J:116444
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:165919
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:142192
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005677	chromatin silencing complex	IDA	J:228292
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:142192
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:157724
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:157068
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:196211
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:157630
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:183475
Cellular Component	GO:0035098	ESC/E(Z) complex	IBA	J:265628
Cellular Component	GO:0035098	ESC/E(Z) complex	IDA	J:281161
Cellular Component	GO:0035098	ESC/E(Z) complex	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617960
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617990
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619411
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619424
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619434
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619436
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619437
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619438
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810138
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810150
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810169
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810170
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:185718
Cellular Component	GO:0005634	nucleus	IDA	J:190157
Cellular Component	GO:0005634	nucleus	ISO	J:148615
Cellular Component	GO:0005634	nucleus	IDA	J:148710
Cellular Component	GO:0005634	nucleus	IDA	J:93445
Cellular Component	GO:0005634	nucleus	IDA	J:47703
Cellular Component	GO:0005634	nucleus	IDA	J:134766
Cellular Component	GO:0005634	nucleus	IDA	J:189224
Cellular Component	GO:0005721	pericentric heterochromatin	IDA	J:240642
Cellular Component	GO:0045120	pronucleus	IDA	J:84664
Biological Process	GO:0030183	B cell differentiation	IMP	J:195518
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IDA	J:211907
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:198334
Biological Process	GO:0035984	cellular response to trichostatin A	IMP	J:211907
Biological Process	GO:0021695	cerebellar cortex development	IMP	J:164377
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	IEA	J:72247
Biological Process	GO:0006306	DNA methylation	IMP	J:202816
Biological Process	GO:0009913	epidermal cell differentiation	IMP	J:148710
Biological Process	GO:0140718	facultative heterochromatin formation	IDA	J:157724
Biological Process	GO:0140718	facultative heterochromatin formation	IDA	J:157630
Biological Process	GO:0070314	G1 to G0 transition	IMP	J:148710
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:148710
Biological Process	GO:0030097	hemopoiesis	IMP	J:195518
Biological Process	GO:0036333	hepatocyte homeostasis	IGI	J:220905
Biological Process	GO:0031507	heterochromatin formation	IBA	J:265628
Biological Process	GO:0070734	histone H3-K27 methylation	IEA	J:72247
Biological Process	GO:0098532	histone H3-K27 trimethylation	IBA	J:265628
Biological Process	GO:0016570	histone modification	ISO	J:155856
Biological Process	GO:0071707	immunoglobulin heavy chain V-D-J recombination	TAS	J:195518
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:148710
Biological Process	GO:0097421	liver regeneration	IGI	J:220905
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IGI	J:218234
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045605	negative regulation of epidermal cell differentiation	IMP	J:148710
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	IMP	J:148710
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	ISO	J:164563
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	IMP	J:148710
Biological Process	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:2000737	negative regulation of stem cell differentiation	IMP	J:148710
Biological Process	GO:0051154	negative regulation of striated muscle cell differentiation	IDA	J:93445
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:202816
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IMP	J:148710
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IMP	J:148710
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1900006	positive regulation of dendrite development	ISO	J:155856
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0071168	protein localization to chromatin	IMP	J:134477
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:148710
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:116444
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:164377
Biological Process	GO:0010468	regulation of gene expression	IMP	J:211907
Biological Process	GO:0014013	regulation of gliogenesis	IMP	J:164377
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:164377
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:148710
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:171612
Biological Process	GO:1904772	response to tetrachloromethane	IGI	J:220905
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IMP	J:171612
Biological Process	GO:0048863	stem cell differentiation	IMP	J:148710
Biological Process	GO:0031509	subtelomeric heterochromatin formation	ISO	J:164563
Biological Process	GO:0051932	synaptic transmission, GABAergic	ISO	J:155856