Rock1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200394
Molecular Function	GO:0005515	protein binding	IPI	J:196108
Molecular Function	GO:0005515	protein binding	IPI	J:196103
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0106003	amyloid-beta complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0010494	cytoplasmic stress granule	IDA	J:259116
Cellular Component	GO:0010494	cytoplasmic stress granule	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IDA	J:196108
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	IDA	J:196108
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:196108
Cellular Component	GO:0001726	ruffle	IDA	J:196108
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:94515
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0031032	actomyosin structure organization	IBA	J:265628
Biological Process	GO:0003383	apical constriction	IGI	J:174450
Biological Process	GO:0003383	apical constriction	IGI	J:174450
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0032060	bleb assembly	IMP	J:120291
Biological Process	GO:0097746	blood vessel diameter maintenance	IMP	J:268013
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0030866	cortical actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0007010	cytoskeleton organization	ISO	J:155856
Biological Process	GO:0048598	embryonic morphogenesis	IBA	J:265628
Biological Process	GO:0001837	epithelial to mesenchymal transition	IGI	J:94515
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050900	leukocyte migration	ISO	J:164563
Biological Process	GO:0050901	leukocyte tethering or rolling	ISO	J:164563
Biological Process	GO:0022614	membrane to membrane docking	ISO	J:164563
Biological Process	GO:0000281	mitotic cytokinesis	IBA	J:265628
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:100207
Biological Process	GO:0061157	mRNA destabilization	IMP	J:268013
Biological Process	GO:0051451	myoblast migration	IMP	J:196103
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:100207
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ISO	J:164563
Biological Process	GO:0042326	negative regulation of phosphorylation	IMP	J:278520
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0140058	neuron projection arborization	ISO	J:164563
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0090521	podocyte cell migration	IMP	J:278520
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:1905205	positive regulation of connective tissue replacement	ISO	J:164563
Biological Process	GO:0035306	positive regulation of dephosphorylation	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	IMP	J:196103
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0010922	positive regulation of phosphatase activity	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IMP	J:278520
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0032970	regulation of actin filament-based process	IGI	J:174450
Biological Process	GO:0032970	regulation of actin filament-based process	IGI	J:174450
Biological Process	GO:0110061	regulation of angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:1901888	regulation of cell junction assembly	IBA	J:265628
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	ISO	J:164563
Biological Process	GO:1990776	response to angiotensin	IGI	J:261839
Biological Process	GO:0071559	response to transforming growth factor beta	ISO	J:155856
Biological Process	GO:0071559	response to transforming growth factor beta	IGI	J:261839
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:136004
Biological Process	GO:0007165	signal transduction	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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