GO Annotations Graph

• Symbol: Myo5a
• Name: myosin VA
• ID: MGI:105976

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IDA	J:100998
Molecular Function	GO:0003779	actin binding	IDA	J:79971
Molecular Function	GO:0003779	actin binding	IDA	J:72800
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0043008	ATP-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	IDA	J:89277
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	IDA	J:217299
Molecular Function	GO:0005516	calmodulin binding	IDA	J:72800
Molecular Function	GO:0005516	calmodulin binding	IDA	J:89277
Molecular Function	GO:0003774	cytoskeletal motor activity	ISO	J:155856
Molecular Function	GO:0003774	cytoskeletal motor activity	IDA	J:72800
Molecular Function	GO:0097718	disordered domain specific binding	IPI	J:240278
Molecular Function	GO:0042802	identical protein binding	IPI	J:248268
Molecular Function	GO:0042802	identical protein binding	IPI	J:245331
Molecular Function	GO:0000146	microfilament motor activity	ISO	J:155856
Molecular Function	GO:0000146	microfilament motor activity	TAS	Reactome:R-MMU-9023194
Molecular Function	GO:0000146	microfilament motor activity	TAS	Reactome:R-MMU-9023204
Molecular Function	GO:0000146	microfilament motor activity	IBA	J:265628
Molecular Function	GO:0000146	microfilament motor activity	IDA	J:89277
Molecular Function	GO:0000146	microfilament motor activity	IDA	J:72800
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:67601
Molecular Function	GO:0005515	protein binding	IPI	J:79971
Molecular Function	GO:0005515	protein binding	IPI	J:87907
Molecular Function	GO:0005515	protein binding	IPI	J:87907
Molecular Function	GO:0005515	protein binding	IPI	J:79971
Molecular Function	GO:0005515	protein binding	IPI	J:79971
Molecular Function	GO:0005515	protein binding	IPI	J:68594
Molecular Function	GO:0005515	protein binding	IPI	J:164092
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IPI	J:191891
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:155856
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0042641	actomyosin	IDA	J:16915
Cellular Component	GO:0042642	actomyosin, myosin complex part	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:40078
Cellular Component	GO:0005737	cytoplasm	IDA	J:37976
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1449591
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2316351
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9023194
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9023204
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0032433	filopodium tip	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:169032
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:169032
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:89391
Cellular Component	GO:0032593	insulin-responsive compartment	IDA	J:191891
Cellular Component	GO:0005882	intermediate filament	IDA	J:16915
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0042470	melanosome	ISO	J:164563
Cellular Component	GO:0042470	melanosome	IDA	J:40078
Cellular Component	GO:0042470	melanosome	IDA	J:105323
Cellular Component	GO:0042470	melanosome	IDA	J:75876
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016459	myosin complex	IDA	J:79971
Cellular Component	GO:0016459	myosin complex	IDA	J:72800
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:11005
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Cellular Component	GO:0001750	photoreceptor outer segment	IDA	J:91408
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	IDA	J:169032
Cellular Component	GO:0098794	postsynapse	IMP	J:169032
Cellular Component	GO:0098794	postsynapse	IDA	J:169032
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	ISO	J:155856
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:155856
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:100746
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IDA	J:169032
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IMP	J:169032
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IDA	J:169032
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0016461	unconventional myosin complex	IMP	J:240278
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Cellular Component	GO:0031982	vesicle	IBA	J:265628
Biological Process	GO:0007015	actin filament organization	IBA	J:265628
Biological Process	GO:0030048	actin filament-based movement	ISO	J:155856
Biological Process	GO:0030048	actin filament-based movement	IDA	J:89277
Biological Process	GO:0042640	anagen	IMP	J:94728
Biological Process	GO:0099640	axo-dendritic protein transport	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:191891
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:92181
Biological Process	GO:0048066	developmental pigmentation	IMP	J:94728
Biological Process	GO:0042417	dopamine metabolic process	ISO	J:155856
Biological Process	GO:0051643	endoplasmic reticulum localization	IMP	J:36532
Biological Process	GO:0051643	endoplasmic reticulum localization	IMP	J:61324
Biological Process	GO:0099089	establishment of endoplasmic reticulum localization to postsynapse	IDA	J:169032
Biological Process	GO:0099089	establishment of endoplasmic reticulum localization to postsynapse	IMP	J:169032
Biological Process	GO:0099089	establishment of endoplasmic reticulum localization to postsynapse	IDA	J:169032
Biological Process	GO:0099089	establishment of endoplasmic reticulum localization to postsynapse	IDA	J:169032
Biological Process	GO:0099089	establishment of endoplasmic reticulum localization to postsynapse	IMP	J:169032
Biological Process	GO:0006887	exocytosis	IMP	J:100746
Biological Process	GO:0048820	hair follicle maturation	IMP	J:232539
Biological Process	GO:0030073	insulin secretion	IMP	J:100746
Biological Process	GO:0031987	locomotion involved in locomotory behavior	IMP	J:58208
Biological Process	GO:0031987	locomotion involved in locomotory behavior	IMP	J:61324
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process	IMP	J:106960
Biological Process	GO:0016236	macroautophagy	ISO	J:155856
Biological Process	GO:0042438	melanin biosynthetic process	IMP	J:28766
Biological Process	GO:0006582	melanin metabolic process	IMP	J:46886
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:11005
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:29467
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:20796
Biological Process	GO:0032400	melanosome localization	IMP	J:37976
Biological Process	GO:0032400	melanosome localization	IMP	J:87907
Biological Process	GO:0032400	melanosome localization	IMP	J:67601
Biological Process	GO:0032402	melanosome transport	IMP	J:111253
Biological Process	GO:0032402	melanosome transport	IDA	J:40078
Biological Process	GO:0032402	melanosome transport	IMP	J:46886
Biological Process	GO:0032402	melanosome transport	IMP	J:209956
Biological Process	GO:0042552	myelination	IMP	J:106960
Biological Process	GO:0033602	negative regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0050885	neuromuscular process controlling balance	IMP	MGI:MGI:61192
Biological Process	GO:0042476	odontogenesis	IDA	J:87907
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:12173
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:47546
Biological Process	GO:0043473	pigmentation	ISO	J:63781
Biological Process	GO:0043473	pigmentation	IMP	J:232539
Biological Process	GO:0043473	pigmentation	IMP	J:20299
Biological Process	GO:0043473	pigmentation	IMP	J:209956
Biological Process	GO:0043473	pigmentation	IMP	J:7092
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:29467
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:47547
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:7092
Biological Process	GO:0043473	pigmentation	IMP	J:7092
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	J:12970
Biological Process	GO:0043473	pigmentation	IMP	J:47547
Biological Process	GO:0043473	pigmentation	IMP	J:47547
Biological Process	GO:0043473	pigmentation	IMP	J:7751
Biological Process	GO:0043473	pigmentation	IMP	J:20796
Biological Process	GO:0043473	pigmentation	IMP	J:25681
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:0043473	pigmentation	IMP	MGI:MGI:61192
Biological Process	GO:0043473	pigmentation	IMP	J:26019
Biological Process	GO:1900078	positive regulation of cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:1904960	positive regulation of cytochrome-c oxidase activity	ISO	J:155856
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0006892	post-Golgi vesicle-mediated transport	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:191891
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0150103	reactive gliosis	ISO	J:155856
Biological Process	GO:0017157	regulation of exocytosis	ISO	J:155856
Biological Process	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IMP	J:107694
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:169032
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	IMP	J:169032
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:169032
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	IDA	J:169032
Biological Process	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	IMP	J:169032
Biological Process	GO:0032252	secretory granule localization	ISO	J:155856
Biological Process	GO:0032252	secretory granule localization	IMP	J:100746
Biological Process	GO:0050808	synapse organization	IMP	J:92181
Biological Process	GO:0030050	vesicle transport along actin filament	ISO	J:164563
Biological Process	GO:0030050	vesicle transport along actin filament	ISO	J:155856
Biological Process	GO:0030050	vesicle transport along actin filament	IBA	J:265628
Biological Process	GO:0030050	vesicle transport along actin filament	TAS	J:72800
Biological Process	GO:0016192	vesicle-mediated transport	IMP	J:191891
Biological Process	GO:0007601	visual perception	IMP	J:92181